PhD student position: elucidating chaperone protein function using single-molecule fluorescence/FRET
9 Mar 2024
Job Information
- Organisation/Company
University of Basel- Research Field
Biological sciences » Other
Chemistry » Biochemistry
Computer science » Other
Physics » Biophysics- Researcher Profile
First Stage Researcher (R1)- Country
Switzerland- Application Deadline
6 Apr 2024 - 21:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
38- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The Biomolecular Nano-Dynamics group at the Dept. of Chemistry, University of Basel is looking for a highly talented and motivated PhD student in biophysical chemistry to join our team for the study of protein dynamics and chaperone function using novel techniques, such as single-molecule fluorescence/FRET and unnatural amino-acid labelling.
This PhD project will grow with you. You will create time-resolved direct observations of single Hsp90 chaperone proteins in action, to push beyond static 3D structures and reveal the essential molecular processes that underlie Hsp90's function, i.e.: to assist protein folding and maturation in health and disease. Multiple critical questions remain unsolved in this regard that you can tackle in your PhD. Steps involved:
- Protein construct design, mutagenesis, purification, bioconjugation, quality control
- Single-molecule fluorescence/FRET/DyeCycling experiments
- Genetic code expansion for site-specific unnatural amino-acid labeling
- Data analysis using existing and self-written code
Prior experience in several of these areas is desired:
- Protein biochemistry (purification, bioconjugation, quality control, etc.)
- Single-molecule experiments and interpretation
- Advanced data analysis, coding, machine learning
- Optics and fluorescence microscopy techniques
Essential requirements:
- MSc degree in (bio-)chemistry, physics, molecular lifesciences with excellent grades
- High motivation and curiosity about fundamental questions in protein science
- Independent analytical thinking and systematic work style
- Excellent experimental problem-solving skills and perseverance
- Friendly team player proficient in English communication (speaking & writing)
- An exciting and fully funded PhD project in Basel, Switzerland
- Embedding in a productive, interdisciplinary group with an open and interactive lab culture
- State-of-the-art research infrastructure and facilities
- A highly international and interdisciplinary setting stimulating your professional and personal development
- The GRACE graduate center
- A beautiful and very livable city at the intersection of Germany, France, and Switzerland
- Wide-ranging sport offers
It goes without saying that we welcome applications of friendly and ambitious humans of all kind.
Application / Contact
Applications are invited before/by April 7th, 2024.
Please submit your application via [email protected] with subject 'Application PhD3 Firstname Lastname', and include:
your letter of motivation, your CV, and email addresses of 2-3 references – all merged into one single pdf file named 'Application PhD3 Firstname Lastname.pdf'.
For questions, please contact Prof. Sonja Schmid: [email protected] .
Requirements
- Research Field
- Biological sciences
- Years of Research Experience
- 1 - 4
- Research Field
- Chemistry
- Years of Research Experience
- 1 - 4
- Research Field
- Computer science
- Years of Research Experience
- 1 - 4
- Research Field
- Physics
- Years of Research Experience
- 1 - 4
Additional Information
- Website for additional job details
https://academicpositions.com
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- University of Basel
- Country
- Switzerland
- City
- Basel
- Postal Code
- CH-4003
- Street
- Petersplatz 1
Where to apply
- Website
https://academicpositions.com/ad/university-of-basel/2024/phd-student-position-…
Contact
- City
Basel- Website
https://www.unibas.ch/en.html- Postal Code
CH-4003
STATUS: EXPIRED
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