PhD position: In vivo gene editing and functional genomics to interrogate brain development and function

27 Feb 2024
Job Information

Organisation/Company

ETH Zurich

Department

Department of Biosystems Science and Engineering

Research Field

Biological sciences » Biological engineering
Neurosciences » Neurobiology
Biological sciences » Biology

Researcher Profile

First Stage Researcher (R1)

Country

Switzerland

Application Deadline

18 Mar 2024 - 12:00 (Europe/Zurich)

Type of Contract

Not Applicable

Job Status

Full-time

Offer Starting Date

15 Aug 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The Laboratory for Biological Engineering (Prof. Randall J Platt) of the ETH Zurich in Basel, Switzerland develops genome engineering technologies and applies them to a range of fundamental and disease-focused areas. To advance these efforts, the Platt group  is recruiting a full-time (100%) PhD Student to develop and apply in vivo functional genomic methods.

Project background

Investigating gene function using direct in vivo screening  is revolutionising the way we study brain biology . We have previously developed AAV-based molecular methods  for direct in vivo CRISPR screening and are continuing to develop novel tools to be able to interrogate new aspects of brain biology.

Job description

We are looking for a highly motivated and collaborative researcher to be integrated in a multidisciplinary team of scientists. The candidate will develop novel molecular methods and apply them to ask fundamental questions about brain development and function in the context of health and disease. The candidate will be passionate about science, technology, collaboration, and communication.

Requirements

Research Field

Biological sciences

Education Level

Master Degree or equivalent

Skills/Qualifications

The ideal candidate should have a Master’s degree or equivalent in Biology, Neurobiology, Molecular Biotechnology, Molecular Medicine, or a related field. The successful candidate will have experience across several of the following areas:

• cloning, molecular biology techniques and synthetic biology
• virus production and/or evolution and delivery (AAV, LV)
• in vivo interrogation of mouse models, including histological techniques, imaging and quantification
• primary cell isolation, cell culture, and flow cytometry
• preparation of deep sequencing libraries for functional genomics experiments
• bioinformatics, statistics, and programming

The candidate must have a strong motivation and interest in collaboration with multi-disciplinary scientists. They must be able to communicate effectively in a highly interdisciplinary and international environment, which includes a mastery of oral and written English as well as scientific illustration using Adobe Illustrator or equivalent.

Languages

ENGLISH

Level

Excellent

Additional Information
Work Location(s)

Number of offers available

1

Company/Institute

ETH Zurich

Country

Switzerland

Geofield

Where to apply

Website

https://jobs.ethz.ch/job/view/JOPG_ethz_Kgz5zLZNDVvY0Jllhw

Contact

State/Province

Basel-Stadt

City

Basel

Website

https://bsse.ethz.ch/platt

Street

44 Schanzenstrasse

Postal Code

4056

STATUS: EXPIRED