PhD position in reverse translational breast cancer research

A PhD position is available in the laboratory of Professor Momo Bentires-Alj (https://bentireslab.org/ ) at the Department of Biomedicine (DBM) in Basel, Switzerland. The successful candidate will work on primary patient breast cancer organoid cultures, proteomics, and image-based drug screening.

Selected publications of our lab include: 1- PIK3CAH1047R induces multipotency and multi-lineage mammary tumors. Koren S, et al., Nature 2015. 2- Hippo kinases LATS1/2 control human breast cell fate via crosstalk with ERα. Britschgi A, et al., Nature 2017. 3. Glucocorticoids promote breast cancer metastasis. Obradović MMS, et al. Nature 2019. 4. Hepatic stellate cells suppress NK cell sustained breast cancer dormancy. Correia AL, et al., Nature 2021.

The tasks include: a) Manage and characterize breast cancer patient-derived organoid samples, b) Assess their response to single or combination therapy using image-based drug screening (Pharmacoscopy); c) Validate the findings in vivo

A strong experience in primary cell culture and imaging. Expertise in drug screening, and/or mouse work is a plus. The candidate should be well-organized, highly motivated, a team player, and must be fluent in English.

A stimulating, challenging and interdisciplinary translational research environment, state-of-the-art technologies and core facilities, and attractive employment conditions. The DBM is an international institute pursuing basic, translational and clinical research, with access to cutting-edge core facilities.

Lab website: https://bentireslab.org/ .

Application / Contact

Please send your CV, a summary of your research experience and interests, techniques that you are competent in, and the contact details of three referees. to Nathalie Laschet: [email protected]

Application deadline: applications will be reviewed as they arrive.