The successful candidate will work on molecular and cellular mechanisms underlying cancer-associated T cell exhaustion. The overall goal of this work is to delineate the metabolic heterogeneity of CD8 T cells in human tumors and characterize key metabolic pathways underlining the development of exhausted T cells. This knowledge will help to develop and implement novel strategies for cancer immunotherapy. Experimental systems include patient-derived tumor infiltrating lymphocytes (TILs), T cell cultures and murine tumor models.
Selected publications of our lab and our close collaborations include:
Voabil et al, Nat Med 2021; Trueb M et al, JITC 2020; Yu YR et al, Nat. Immunol 2020; Wang et al, Nat. Immunol 2020; Claus et al, Science Transl Med 2019; Trefny et al, Clin Cancer Res 2019; Cheng, Nat. Immunol 2019; Stanczak, J Clin Invest 2018; Thommen, Nat Med 2018
Post Doctoral Position: Cancer & Metabolism Uc Louvain, Brussels, Belgium, UCLouvain, Belgium, 6 days ago
A 3-year position is available for a postdoctoral scientist to conduct a research project in oncology with a focus on tumor metabolism. Two axes will be considered: (i) the interplay between the t...
Ph D Student In Cancer Research, Luxembourg Institute of Health, Luxembourg, 1 day ago
Background. Chronic Lymphocytic Leukemia (CLL) represents the most frequent leukemia in adults. Despite recent advances in treatments, CLL remains a deadly incurable disease. This cancer is charac...
Postdoctoral Position In Cancer Systems Biology | Hebrew University Of Jerusalem, Hebrew University of Jerusalem, Israel, 22 days ago
The Drier lab for systems biology of cancer at the Hebrew University of Jerusalem is recruiting a postdoctoral research associate to systematically study how non-coding DNA alterations drive canc...
Ph D Scholarship: Ubiquitin Signalling Mechanisms In Inflammatory Disease, Technical University of Denmark, Denmark, 23 days ago
A 3-year PhD Scholarship starting 1 May 2022 is available in the Ubiquitin Signalling and Inflammation Laboratory led by Associate Professor Rune Busk Damgaard. Our mission The mission in the Ubiq...
Postdoctoral Studies In Skin Stem Cell Biology & Regenerative Medicine (Scholarship), Karolinska Institutet, Sweden, about 11 hours ago
Do you want to contribute to improving human health? Division Kasper Lab: With our research – rooted within the fields of skin and stem cell biology – we aim to answer fundamental questions about ...
Doctoral (Ph D) Student Position In Human Tumor Immunology, Karolinska Institutet, Sweden, about 11 hours ago
We are seeking a highly motivated student to join the team of Andrea Ponzetta as a PhD student to investigate the dynamic alterations of the immune infiltrate during human gastroesophageal cancer ...