PhD in Engineering/Microsystems Engineering: Droplet Microfluidics for Reactions and Drug Screening

100%, Basel, fixed-term

The Bioanalytics Group at the Department Biosystems Science and Engineering/ ETH Zurich in Basel develops a new generation of analytical instruments and methods for applications across the life sciences using microsystems technology.

Project background

Fast, efficient and sensitive: Reactions and analysis in nanoliter reactors . We offer a PhD position for an engineer to contribute to our team efforts in realization of so-called microdroplet arrays, which are used for high throughput biotechnology, biochemical reactions and drug screening.The Phd thesis has an emphasis in the improvement of design, fabrication and surface modifications of microdroplet arrays.

High-throughput screening methods are required to produce, find, test and analyze new compounds and effective drugs. To address this challenge, we employ droplet microfluidics, which allows for creation of thousands of tiny reaction vessels at high frequency of up to several kHz. The resulting emulsion has an excellent monodispersity, with droplet volumes in the range of pico- to nanoliters. The technique is used in combination with optical methods such as fluorescence spectroscopy. In addition, we use mass spectrometry for more detailed analysis of the enclosed compounds or reaction products.

The combination of biological and technological aspects is central in our group. The realization of cutting-edge methods requires team work of researchers with different background. We are looking for a PhD candidate, who has strong disposition to address technological challenges, learn and improve methods and is very open to different research disciplines. Ideally, the start is in late spring (April 2024).

Job description

The PhD candidate will work closely together with other team members on a highly interdisciplinary topic. Central in the work is the fabrication of microstructured targets, which will be done in the Department`s clean room.

Other tasks:

• surface modification, characterization of surfaces and development of bioassays on surfaces
• establish workflows for data acquisition and analysis
• writing scientific publications
• involvement in teaching: supervision of students`projects and lab course

Your profile

We are looking for highly motivated candidates with:

• a strong interest to work at the interface of applied topics in the natural sciences/life sciences, and technology development
• a Master`s Degree in Engineering/Microsystems Engineering or related fields
• practical experiences in microfabrication and work in a clean room

Previous experiences in the field of microfluidics/lab-on-chip technology are helpful.

Your workplace

Your workplace

We offer

We offer you an intellectually challenging position in the inspiring atmosphere of an interdisciplinary team. The PhD candidates will start in our brand-new building in the centre of Basel, offering excellent infrastructure and working conditions. Further information about our group and the Department can be found on the websites Bioanalytics Group and Department of Biosystems Science and Engineering .

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Curious? So are we.

We look forward to receiving your online application with the following documents (latest January 31, 2024):

• A letter describing your background and motivation
• CV
• Two reference letters
• Certificates (doctoral degree, master certificate)

Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.

Questions regarding the position should be directed to Prof. Petra S. Dittrich, email ([email protected]) (no applications).

About ETH Zürich

ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.