PhD Project on Nanotechnologies

• English

PhD Project on Nanotechnologies for Selective Cardiac Delivery of proANP31-67 in acute Myocardial Infarction and Vibrational Spectroscopy for detection of novel biomarkers of early cardiac damage  

This study will generate knowledge on the effects of direct cardiac supplementation of a new medication, the cardiac hormone proANP31-67. While the systemic effects of this protein have been previously reported, we will investigate, for the first time, the direct actions on the heart of this hormone in post-MI. The use of nanoparticles will generate new knowledge, as these carriers have not been tested in models of cardiac diseases yet. The use of combined FTIR and Raman for monitoring the therapeutic effects of our investigational drug and new delivery technology is also new in the cardiovascular field. The project will also require the use of advanced cellular imaging techniques (confocal microscopy) and experiments focused on cellular and molecular biology. The project has highly qualified national and international collaborators. The potential candidate must be open to short-term periods abroad to complete certain aspects of the project at the location of our international collaborators.  

We are currently seeking applicants for a 3-year PhD position focused on treating acute myocardial infarction (MI) through the use of a new medication and innovative delivery system. This position will be based at the Institute for Experimental Medical Research (IEMR) located at Oslo University Hospital / University of Oslo. IEMR is an innovative and dynamic medical research environment that conducts research focused on understanding the molecular basis of cardiac disease and heart failure development. With approximately 70 employees and six research groups, our expertise spans molecular biology, physiology and cardiology. The project will be supervised by Professor Alessandro Cataliotti, MD, PhD, whose research team is involved in international collaborations, and has access to cutting-edge research environments. The objective of the fellowship is to prepare researchers to assume higher academic roles within their respective fields.

The PhD position will last for three years and, depending on the starting date, the contract will end no later than the end of 2026. The funding for this position will be provided through a grant from Nasjonalforeningen for folkehelsen.

The research fellow must take part in the University’s/ Faculty’s/ Department’s approved PhD program and is expected to complete the project within the set fellowship period. The main purpose of the fellowship is research training leading to the successful completion of a PhD degree.

 For more information, please see our web site Application and admission - PhD - Faculty of Medicine (uio.no)

We ask all applicants to respond to the qualification requirements. We will not consider applications lacking this information.

• We are looking for talented and highly motivated candidates of all nationalities who have a keen interest in cellular and cardiovascular research
• Applicants must hold a degree equivalent to a Norwegian Masters's degree in Biology, Biotechnology, Biomedical Laboratory Sciences or Medical/Health/Social subjects
• Previous experience with molecular technology, and nanotechnology will be viewed as an asset
• Willing to work with animal models
• Fluent oral and written communication skills in English

Value will be placed on the compatibility of the applicant’s professional and personal disposition, with strengths in:

• Systematic approach
• Analysis and assessment
• Implementation
• Self-development
• Initiative and accountability
• Enthusiastic, reliable and structured
• Genuine interest in research
• Dedicated and responsible.

• Salary in the range of pay grade 532 200 – 575 400 NOK/year depending on qualifications
• A stimulating, challenging and friendly international working environment with broad expertise
• Technical assistance and training
• Attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities.

The application must include

• cover letter statement of motivation and research interests
• CV (summarizing education, positions and academic work)
• copies of educational certificates (academic transcripts only)
• a complete list of publications and academic works
• list of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number)

The application with attachments must be delivered in our electronic recruiting system, please follow the link “apply for this job”. Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English (or a Scandinavian language).

When evaluating the application, emphasis will be given to the eventuelt “project description” and the applicant’s academic and personal prerequisites to carry out the project. Applicants may be called in for an interview.

Please see the guidelines and regulations for appointments to Research Fellowships at the University of Oslo.

No one can be appointed for more than one PhD Research Fellowship period at the University of Oslo.

According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.

The appointment may be shortened/given a more limited scope within the framework of the applicable guidelines on account of any previous employment in academic positions.

The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.

Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition. Furthermore, we want employees with diverse professional expertise, life experience and perspectives.

If there are qualified applicants with disabilities, employment gaps or immigrant background, we will invite at least one applicant from each of these categories to an interview.

Professor Alessandro Cataliotti, email: [email protected]

The University of Oslo is Norway’s oldest and highest ranked educational and research institution, with 28 000 students and 7000 employees. With its broad range of academic disciplines and internationally recognised research communities, UiO is an important contributor to society.

The Institute of Clinical Medicine (Klinmed) is one of three institutes under the Faculty. Klinmed is responsible for the Faculty's educational and research activities at Oslo University Hospital and Akershus University Hospital. With about 800 employees spread over approximately 425 man-labour years, Klinmed is the university's largest institute. Our activities follow the clinical activity at the hospitals and are spread across a number of geographical areas.

Institute for Experimental Medical Research - Institute of Clinical Medicine (uio.no )

7th January 2024

University of Oslo

Oslo

Scope

Fulltime (1 positions) Fulltime (%)

Fixed Term

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