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collaboration between the Molecular Biosensing and the Protein Engineering research groups at TU/e (see www.tue.nl/mbx and https://merkxlab.nl/ ). Their fields of expertise on continuous biosensing and protein
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Molecular Biosensing and the Protein Engineering research groups at TU/e (see www.tue.nl/mbx and https://merkxlab.nl/ ). Their fields of expertise on continuous biosensing and protein engineering are
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has long focused on the toxic effects of the HTT-encoded polyglutamine protein that aggregates in neurons. However, recent discoveries reveal that the HTT mRNA itself forms condensates and aggregates
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polyglutamine protein that aggregates in neurons. However, recent discoveries reveal that the HTT mRNA itself forms condensates and aggregates, contributing to neuronal toxicity. In this project, your work will
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acceptance remains limited due to insufficient meat aroma and persistent off-flavors. PBMAs are typically produced by texturizing plant proteins through extrusion or shear cell processing, both of which
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protein-ligand interactions and protein-peptide interactions. The candidate will work in an interdisciplinary environment, combining experimental approaches (single molecule fluorescence and biochemistry
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of heterobispecific Fc format using protein engineering focusing on humanization and improved stability. Generation of high affinity minibinders for blood coagulation factors based on "in silico affinity maturation
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collaboration with the Protein Engineering research group (https://merkxlab.nl/ ) and the Institute for Complex Molecular Systems (www.tue.nl/icms ). The research group initiated and organizes the international
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PhD candidate for the project "Modulation of inflammatory Dendritic cell subsets in atherosclerosis"
atherosclerosis and to develop innovative biopharmaceutical concepts to intervene in cardiovascular disease. The use of specific gene-knockout technology, biologics such as vaccines, therapeutic proteins and
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and prothrombin. Wet lab production and screening of the aforementioned binders. Optimization of heterobispecific Fc format using protein engineering focusing on humanization and improved stability