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. You will use human in vitro models, including astrocytes and brain organoids generated from induced pluripotent stem cells (iPSCs) of people with MLC and healthy controls. You will investigate disease
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physiologically relevant human in vitro model of Pelizaeus-Merzbacher-like disease type 1 (PMLD1). You will first test leading AAV capsids developed by Myrtelle Therapeutics Inc. in the in vitro model. You will
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to contact (Lionel. Hirschberg ([email protected] ) About the organisation At the Faculty of Engineering Technology (ET), we work on engineering for impact: developing smart, sustainable, human-centred
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, Cognition and Behaviour is a world-class interfaculty research centre that houses more than 700 researchers devoted to understanding the mechanistic underpinnings of the human mind. Research at the Donders
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intermediate research results at workshops and conferences; participation in the ARTES Research School and Faculty of Humanities PhD training programmes; (co-)teaching courses at BA-level in the second and third
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PFAS are among the most challenging contaminants facing drinking water utilities worldwide. Although granular activated carbon (GAC) is widely applied for PFAS removal, utilities face challenges
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regulators are then validated biochemically, in cellular and in vivo models of PD, and finally in human post-mortem midbrain tissue, so that you can connect a molecular mechanism to the disease itself. You
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liquid biomarkers for leukodystrophies by integrating multi-omics data from patient plasma and iPSC-derived human disease models. You will investigate disease-related molecular signatures using
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Amsterdam, and the successful candidate will work primarily from here. Faculty of Social Sciences and Humanities A better understanding of ourselves and social communities, values and meaning, through social
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science, human nutrition and behavioural research and will involve close collaboration with clinical partners. As part of your PhD trajectory, you will: conduct high-quality scientific research within