PhD Student in Nanopore sequencing-based characterization of brain tumors for pre-operative diagnosis
25 Jan 2024
Job Information
- Organisation/Company
Luxembourg Institute of Health- Department
Ressources Humaines- Research Field
Computer science
Biological sciences » Other- Researcher Profile
First Stage Researcher (R1)- Country
Luxembourg- Application Deadline
29 Feb 2024 - 15:01 (Europe/Luxembourg)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
40- Offer Starting Date
1 Apr 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The Multi-omics Data Science Group is part of the Department of Cancer Research at LIH. We focus on various modalities of high-throughput molecular data obtained in cancer biology. We aim to integrate corresponding data layers to improve our understanding of cancers and drive better patient stratification and treatment. Dr. Reka Toth, the PI of the project, has expertise in epigenetics, bioinformatics and multi-omics profiling.
Project
We are looking for a curious, agile and committed PhD student to join the NANO-SCOPE project, funded by FNR CORE.
Brain and central nervous system (CNS) tumors are rare and heterogeneous, with gliomas having a poor prognosis. The current gold standard for diagnosis is invasive and time-consuming. Liquid biopsies, such as cell-free DNA (cfDNA) from cerebrospinal fluid (CSF), are promising for less invasive and faster diagnosis. However, an accurate method for establishing a DNA methylation-based molecular diagnosis of CNS tumors before surgery is still missing. Our study aims to develop a diagnostic tool using Nanopore sequencing-based DNA methylation patterns from cfDNA to molecularly classify brain tumors before surgery, potentially improving prognosis and reducing time to diagnosis.
The project is primarily computational, with some wet laboratory components. The latter is supported by PD Dr. Katrin Frauenknecht (LNS, Luxembourg). As part of our team, we offer a vibrant multidisciplinary and multinational working environment and strong support, fostering collaboration and innovation. The University of Luxembourg and LIH offer comprehensive training in both scientific advancements and essential soft skills.
Scientific contacts
Dr. Reka Toth ([email protected] )
Key Responsibilities
- Participate in the setting-up and implementation of the research project
- Conduct a research project with the aims of submitting a PhD thesis dissertation and obtaining a PhD degree
- Publish results in scientific journals
- Participate in training and international scientific conferences
- Disseminate results to the scientific community and the public
- Participate in laboratory activities including seminars and interaction with other teams
Requirements
- Research Field
- Biological sciences » Other
- Education Level
- Master Degree or equivalent
Skills/Qualifications
Key Skills, Experience and Qualifications
- Master’s degree in the biomedical/bioinformatical field with an interest in computational biology and machine learning
- Previous experience in bioinformatics, R and/or Python programming
- Wet laboratory and analytical skills, and experience with next-generation or long-read sequencing is a strong asset
- Scientific creativity and originality, precise perseverance, writing skills, good communication skills
- Language skills: fluent command of English; knowledge of other languages of the European Union is an asset.
- Languages
- ENGLISH
- Level
- Good
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Luxembourg Institute of Health
- Country
- Luxembourg
- City
- STRASSEN
- Postal Code
- L-1445
- Street
- rue Thomas Edison
- Geofield
Where to apply
- Website
https://odoo.lih.lu/jobs/detail/phd-student-nanopore-sequencing-based-character…
Contact
- State/Province
Strassen- City
Strassen- Website
http://www.lih.lu- Street
1A-B, rue Thomas EdisonL-1445 StrassenLuxembourg- Postal Code
1445
STATUS: EXPIRED
Similar Positions
-
Ph D Position In Quantum Information Theory, University of Luxembourg, Luxembourg, about 12 hours ago
The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 s...
-
Ph D Candidate In Smart European Electricity Markets, University of Luxembourg, Luxembourg, about 13 hours ago
Successful candidates will join the young, vibrant, and interdisciplinary FINATRAX Research Group, which builds bridges between electricity markets and digital technologies in Luxembourg. Together...
-
Doctoral Candidate (Ph D Student) In The Field Of Soft Matter Physics, University of Luxembourg, Luxembourg, 3 days ago
The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 s...
-
Ph D Position In Civil Engineering, University of Luxembourg, Luxembourg, about 13 hours ago
The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character. The University was founded in 2003 and counts more than 6,700 s...
-
Ph D Candidate In Software And System Verification, Model Checking, Cyber Physical Systems, University of Luxembourg, Luxembourg, about 13 hours ago
As the successful candidate, you will join the Security, Reasoning and Validation (SeRVal) group of the SnT, under the supervision of Dr. Maxime Cordy. You will contribute more specifically to the...
-
Doctoral Candidate (Ph D Student) In The Field Of Spaceborne Global Navigation Satellite System Reflectometry, University of Luxembourg, Luxembourg, about 13 hours ago
HORIZON EUROPE - MARIE SKŁODOWSKA-CURIE ACTIONS - DOCTORAL NETWORKS GNSS-R SATELLITE EARTH OBSERVATION (GLITTER) The Geophysics and remote Sensing (GRS) Laboratory is dedicated to addressing criti...