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project that aims to generate a hiPSC-based preclinical model for DDX3X syndrome, a rare neurodevelopmental disease caused by germline mutations in the RNA helicase and innate immune signalling adaptor
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rare neurodevelopmental disease caused by germline mutations in the RNA helicase and innate immune signalling adaptor molecule DDX3X The Project The project will then use the new cellular model
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that variants have on PR-DUB and PRC1 function - using methods such as CUT&Tag, Captify, RNA-seq, immunoprecipitation followed by mass spectrometry and high throughput pooled CRISPR screens. The role
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Post Doctoral Researcher / Senior Post Doctoral Researcher - School of Biochemistry and Cell Biology
requires utilizing Python and R to process complex RNA-seq datasets, including differential gene/isoform expression and isoform switching. The researcher will also engage in cancer genomics workflows
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Post Doctoral Researcher / Senior Post Doctoral Researcher - School of Biochemistry and Cell Biology
work at the interface of academia and industry processing, analyzing and interpreting single-cell RIBOseq and RNA-seq data to build a comprehensive knowledge base for ovarian cancer target discovery