6 Apr 2024
Job Information
- Organisation/Company
CNRS- Department
Institut de Chimie des Substances Naturelles- Research Field
Chemistry
Biological sciences
Pharmacological sciences- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
26 Apr 2024 - 23:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
35- Offer Starting Date
1 Oct 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
ICSN - CNRS - UNIVERSITÉ PARIS SACLAY
Gathering a 200-collaborator staff, the ICSN is the chemistry center of the CNRS campus in Gif sur Yvette. The Institute belongs to the Paris-Saclay University Campus, which incorporates 10% of the French research. The ICSN develops research activities at the boundary between chemistry and biology, that draw inspiration from natural substances. ICSN is organised into four research departments and has important analytical platforms
n order to navigate our volatile environment, we constantly rely on our sense of smell. In mammals, it is now well established that olfactory receptors play an important role in olfaction and other crucial developmental and physiological processes, some of which are associated with serious health issues. The exact molecular mechanism by which olfactory receptors accomplish their function is not fully understood and requires atomic-scale information, which has been largely lacking. This is a relatively understudied family of proteins, even though it represents nearly half of the large family of G protein-coupled receptors, primarily because, until recently, there were no experimental structures of mammalian olfactory receptors. The lack of expression of olfactory receptors in eukaryotic cell models used for expressing recombinant membrane proteins is the main obstacle in addressing this challenge. We have succeeded in unlocking their expression in a cell model through the construction of "consensus" receptors that summarize all the properties of human olfactory receptors, allowing us to publish the first structure of an olfactory receptor this year. The project will focus on studying the expression of innovative olfactory receptor constructs on the surface of HEK cells using flow cytometry, as well as measuring their response to odorant molecules of interest for perfumery and drug design. The visualization and characterization of the structures of these receptors and their binding with odorant molecules will be conducted through molecular modeling. This thesis will therefore involve methods of biochemistry, cell culture, and molecular modeling.
Minimum publication during the PhD: one review article, one protocol, and two research articles. Possibility of collaboration with the Monell Center, Duke University, University of California San Francisco, and City of Hope (USA).
Requirements
- Research Field
- Chemistry
- Education Level
- Master Degree or equivalent
- Research Field
- Biological sciences
- Education Level
- Master Degree or equivalent
- Research Field
- Pharmacological sciences
- Education Level
- Master Degree or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Chemistry
- Years of Research Experience
- None
- Research Field
- Biological sciences
- Years of Research Experience
- None
- Research Field
- Pharmacological sciences
- Years of Research Experience
- None
Additional Information
Additional comments
Funding: ANR (obtained) or graduate school contest (ITFA of the Université Paris Saclay)
- Website for additional job details
https://emploi.cnrs.fr/Offres/Doctorant/UPR2301-CLADEM-001/Default.aspx
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Institut de Chimie des Substances Naturelles
- Country
- France
- City
- GIF SUR YVETTE
- Geofield
Where to apply
- Website
https://emploi.cnrs.fr/Candidat/Offre/UPR2301-CLADEM-001/Candidater.aspx
Contact
- City
GIF SUR YVETTE- Website
https://icsn.cnrs.fr
STATUS: EXPIRED
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