PhD scholarship in Receptor Tyrosine Kinase (RTK) signalling in cancer cells - DTU Bioengineering

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PhD scholarship in Receptor Tyrosine Kinase (RTK) signalling in cancer cells - DTU Bioengineering
Kgs. Lyngby, Denmark
Job Description

If you are passionate about and have experience in mammalian cell signalling; you are interested in answering to biomedical questions using technologies and bioinformatics; and your career dream is to be at the forefront of cancer cell signalling, this three years PhD scholarship at DTU Bioengineering will fulfil your scientific and personal development in an international, dynamic, and curiosity-driven research team. 

This position will be affiliated with the team of Associate Professor Chiara Francavilla in the Section for Protein Science and Biotherapeutics at the Department of Biotechnology and Biomedicine, Danish Technical University. The successful candidate will work on regulatory mechanisms of cell signalling downstream of Receptor Tyrosine Kinases (RTKs) in cancer cells and will combine omics technologies, bioinformatics, and functional assays. Therefore, this PhD scholarship offers the unique and exciting opportunity to combine experiments and data analysis. 

Dr Francavilla’s team is funded by the Novo Nordisk Foundation and focuses on regulatory mechanisms of cell signalling in several cellular models by combining omics technologies, bioinformatics, and functional validation of candidates (see Smith, Ferguson et al., EMBO J., 2021; Watson, Ferguson et al., Nat Comm, 2022; Parsons et al, BioRxiv, 2023). This international, passionate, and multidisciplinary team works in close collaboration with the Francavilla-led team at the University of Manchester, UK, and with several scientists with diverse background in Denmark and abroad.

Responsibilities 

• to perform analysis of mammalian cell culture in two- and three-dimension cell culture 
• to perform quantitative, biochemical, and imaging-based analysis of cell signalling and other cell parameters in perturbed mammalian cell culture conditions
• to prepare samples for multi omics analysis using mass spectrometry and other technologies
• to analyse data in collaboration with bioinformaticians
• to validate candidates from omics multi-analysis in two- and three-dimension cell cultures with functional assays
• to perform validation assays in clinical-relevant settings in collaboration with experts in Denmark and abroad
• to take initiatives and responsibilities in the planning of research activities, including working in close collaboration with other team members (bioinformatician, master students) and external collaborators 
• to be updated with relevant literature and novel methodologies
• to participate to training courses and to teaching activities
• to maintain and regularly share with the team accurate and complete records of all findings 
• to participate to regular discussion and presentation of findings to the team, the supervisory team (as agreed), and the scientific community (e.g. by attending conferences) also promoting the reputation of the laboratory, department, and DTU
• to write and submit publications to refereed journals
• to teach, supervise, encourage, and set a positive example for undergraduate students, and to be co-supervisor for Master students
• to undertake administrative tasks within the Department as agreed

Qualifications (required)

• A two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree
• Up-to-date theoretical knowledge and proven experience in mammalian cell culture (especially three-dimensional cell culture), and in the field of cell signalling 
• Up-to-date theoretical and proven experience in biochemistry (Western blots, RT-qPCR, etc), and in imaging (immunofluorescence, confocal microscopy, and flow cytometry), and mammalian cell biology (functional assays like proliferation and migration)
• Up-to-date theoretical and proven experience in sample preparation for quantitative proteomics, phosphoproteomics, and RNA sequencing
• IT skills (Office, Adobe, GraphPad, Image J, etc)
• Excellent interpersonal and communication skills and ability to work with colleagues at all levels
• Excellent written and spoken English
• Excellent time management and organisational skills
• Flexible approach to dealing with research problems as they arise
• Be enthusiastic, committed, hard-working, and self-motivated in an international environment

Approval and Enrolment 
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see DTU's rules for the PhD education . 

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation, and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.

The expected start date is November 15, 2024.

You can read more about career paths at DTU here .

Further information 
Further information may be obtained from Associate Professor Chiara Francavilla: [email protected]

You can read more about DTU Bioengineering at https://www.bioengineering.dtu.dk

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark . Furthermore, you have the option of joining our monthly free seminar “PhD relocation to Denmark and startup “Zoom” seminar ” for all questions regarding the practical matters of moving to Denmark and working as a PhD at DTU. 

Application procedure 
Your complete online application must be submitted no later than 15 April 2024 (23:59 Danish time). 

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

• Application (cover letter) mentioning how you meet all the qualifications
• Curriculum vitae 
• Grade transcripts and BSc/MSc diploma (in English) including official description of grading scale 
• At least one reference letter

You may apply prior to ob­tai­ning your master's degree but cannot begin before having received it. 

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science industry and point towards innovation, new businesses, and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

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Job Info

• Job Identification 3361
• Job Category Phd
• Posting Date 03/19/2024, 03:02 AM
• Apply Before 04/15/2024, 05:59 PM
• Locations Bygningstorvet 116B, Kgs. Lyngby, 2800, DK

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