PhD scholarship in Diamond based Intracellular NMR and Cell Mechanics – DTU Health Tech

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PhD scholarship in Diamond based Intracellular NMR and Cell Mechanics – DTU Health Tech
Kgs. Lyngby, Denmark

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Job Description

The MR by Optics group is looking for a new colleague. In the group, we work with methodology to combine defect-center based diamond sensing with other techniques and assays to assess the mechanical properties of single cells. Our ultimate goal is to carry out single cell NMR based on NV-centers in diamond, and your project is an important part of that journey. The project seeks to answer questions on the coupling between cell metabolism and cellular mechanical properties, the former addressed by NMR, the latter addressed by either optical trapping methodologies or by tuning the mechanical stiffness by varying the substrate involved in the cell growth. We currently work with two different cell models to address the question, an immune cell model and a cardiac cell model. Depending on your profile and results in the initial phase of the project, we may decide to focus on one of these, or include even further cell models.
You will join a group of researchers with training in physics, cell biology, nanoscience, biochemistry and materials science. The group was started in 2020, in new laboratory facilities, and your PhD project will take advantage of insights and developments obtained by other researchers/Ph.D. students in the group. We expect you to bring in complementary competencies as detailed below. 
Responsibilities and qualifications
You will work in the interdisciplinary span between biological physics, optics, and electrical engineering, coupled with aspects of cell biology. We are looking for a candidate with competencies within applied engineering or physics that have demonstrated experience in “making things work”, yet with an open mind towards learning the wonders and intricacies associated with working with single cells. Your first task will be to characterize the chosen biological model systems working with cell ensembles where cell metabolism is measured with NMR spectroscopy. The ensemble system will subsequently be translated to single cell NV-diamond based NMR measurements. At the same time, you will work with your fellow Ph.D. students to refine the NV-diamond experimental setup. Once completed, you will carry out NV-diamond based sensing measurements that at the same time address our mechanobiological questions. Thus, your primary tasks will be to:

• Conduct standard NMR metabolomics.
• Implement and apply NV-diamond based (N)MR measurements
• Contribute to the development of the experimental setup and associated experimental assays

Your degree may be in biomedical engineering, physics, nanoscience, or similar. We prefer a candidate with one or several of the following qualifications:

• Experience with writing software in python to control home-built experimental apparatus.
• Previous experience working with home-built optical setups
• Previous experience with NV-diamond based sensing is an asset, but not a requirement.
• Previous experience with biological physics and/or mammalian cells is an asset, but not a requirement.
• Applicable knowledge on NMR spectroscopy

You must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.
Approval and Enrolment 
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see DTU's rules for the PhD education . 
Assessment
The assessments of the applicants will be made by the main supervisor, Kirstine Berg-Sørensen, and co-supervisors Pernille Rose Jensen and Aldona Mzyk.
We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.
Salary and appointment terms 
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.
The period of employment is 3 years. Preferred starting date: 1 June 2024, according to mutual agreement. 
You can read more about career paths at DTU here .
Further information
Further information may be obtained from Associate Professor Kirstine Berg-Sørensen ([email protected] ). 
You can read more about DTU Health Tech at www.healthtech.dtu.dk  and about the research group at www.healthtech.dtu.dk/magnetic-resonance-by-optics .
If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark . Furthermore, you have the option of joining our monthly free seminar “PhD relocation to Denmark and startup “Zoom” seminar ” for all questions regarding the practical matters of moving to Denmark and working as a PhD at DTU. 
Application procedure 
Your complete online application must be submitted no later than 15 March 2024 (23:59 Danish time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

• A letter motivating the application (cover letter)
• Curriculum vitae 
• Grade transcripts and BSc/MSc diploma (in English) including official description of grading scale.
• The name and contact information of two references.

You may apply prior to ob­tai­ning your master's degree but cannot begin before having received it. 
Applications received after the deadline will not be considered.
All interested candidates irrespective of age, gender, race, disability, religion, or ethnic background are encouraged to apply.
DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Tech’s expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies. The department has a scientific staff of about 210 persons, 140 PhD students and a technical/administrative support staff of about 160 persons, of which a large majority contributes to our research infrastructure and related commercial activities.
Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

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Job Info

• Job Identification 3186
• Job Category Phd
• Posting Date 02/14/2024, 06:20 AM
• Apply Before 03/15/2024, 06:59 PM
• Locations Ørsteds Plads, Kgs. Lyngby, 2800, DK

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