PhD student for the Laboratory of cellular and molecular immunology

1 May 2024
Job Information

Organisation/Company

Biomedical Campus Krč

Department

Laboratory of cellular and molecular immunology

Research Field

Biological sciences » Biology

Researcher Profile

First Stage Researcher (R1)

Country

Czech Republic

Application Deadline

6 Jun 2025 - 19:17 (Europe/Prague)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

40

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The Laboratory of Cellular and Molecular Immunology MBU AS CR is looking for a highly motivated PhD student to collaborate in the project focusing on the role of the microbiome in the pathogenesis of psoriasis. This project has significant implications for clinical medicine. The main aim of your work would be to distinguish subtypes of patients with psoriasis based on clinical characteristics, molecular signatures and the specific composition of their microbiota. This characterisation will help to predict the success of the biological therapy and thus has potential to tailor the appropriate therapy.

 

Specific goals:
1) To identify consortia of bacteria, specific bacteria or a specific microbial profile characteristics for patients using NGS. With this knowledge, specify the role of microbiota in the pathogenesis of this disease
2) To specify the role of the microbiota in the immune response of patients with psoriasis
3) To identify new serum biomarkers enabling to monitor and predict the therapy response in obese patients with psoriasis. Identify specific biomarkers profile for prediction so-called super-responsiveness to biological treatment
4) To analyze the role of obesity in the pathogenesis of psoriasis using spatial transcriptomics, NGS profiling of the skin and gut microbiota as well as using the in vivo and gnotobiotic techniques

Requirements

Research Field

Biological sciences » Biology

Education Level

Master Degree or equivalent

Specific Requirements

Positive attitude towards laboratory work, willingness to learn new methods
Strong interest in immunology and microbiology
Reliability, diligence, ability to work independently and in a team
Training in biological, medical or biochemical fields
Excellent communication skills, knowledge of English (written and spoken)

Languages

ENGLISH

Level

Excellent

Research Field

Biological sciences » Biology

Additional Information
Benefits

perspective, interesting and meaningful job
secure funding for research, including the tenure from the grant
6 weeks holiday
other employee benefits: Multisport card, Flexi-Pass, contributions for employees - also for family members (after the 1st year of employment)
option to work from home
meal vouchers

Selection process

The application should include a CV and motivation letter
More information and submission of applications, please, write to:
Dr. Zuzana Jirásková Zákostelská, email: [email protected]

 

Boarding:
as agreed - as soon as possible

Work Location(s)

Number of offers available

1

Company/Institute

Institute of Microbiology of the Czech Academy of Sciences

Country

Czech Republic

Geofield

Where to apply

E-mail

[email protected]

Contact

City

Prague

Website

https://mbucas.cz/wp-content/uploads/2024/03/výběrové_řízení_MBÚ_formulář_phdstudent_psoriaza.pdf

Street

Vídeňská 1083

Postal Code

14220

E-Mail

[email protected]

STATUS: EXPIRED