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dysregulation of omnipresent and constantly expressed ARS proteins leads to dying-back neurodegeneration and affects specifically the peripheral neurons (PNs). This neuronal population contains the most polarized
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of this proposal is to understand why and how dysregulation of omnipresent and constantly expressed ARS proteins leads to dying-back neurodegeneration and affects specifically the peripheral neurons (PNs
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the use of human iPSC-derived neuronal cultures. Patient fibroblasts, PBMCs, brain tissue and clinical data have been collected and are available in the Dermaut lab, while spatial low-input proteomics
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neurodegenerative diseases. Over the last decade, organoids emerged as an attractive middle ground between 2D cell cultures, which do not fully recapitulate the 3D environment and animal models, which pose technical
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PhD position: Linking neurodevelopmental disorders and mitochondria in human neurons, using iPSC and xenotransplantation We are looking for an ambitious PhD student with a broad interest in
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, organoids emerged as an attractive middle ground between 2D cell cultures, which do not fully recapitulate the 3D environment and animal models, which pose technical and ethical limits. In particular
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the microscopy core facility (ACAM ). The group of Peter Ponsaerts (Laboratory of Experimental Hematology ) houses experts in organoid culture and has studied and developed a variety of iPSC-derived models in
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The team is seeking an enthusiastic lab technician to investigate a series of novel candidate Alzheimer drugs. The assays include sophisticated human neuronal cell culture, Elisa, proteomics, and in vivo
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specifically the peripheral neurons (PNs). This neuronal population contains the most polarized cells in our body and their sophisticated morphology and function render them highly susceptible to degeneration
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dysregulation of omnipresent and constantly expressed ARS proteins leads to dying-back neurodegeneration and affects specifically the peripheral neurons (PNs). This neuronal population contains the most polarized