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Field
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national and international recognition. The Randall Laboratory studies virus-host interactions to understand viral replication and pathogenesis, with a focus on medically important RNA viruses including
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cells with tailor-made error-correcting codes. The successful candidate will combine computational design with laboratory work, developing DNA/RNA systems, molecular circuits, and experimental assays
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an exceptionally motivated, innovative, and independent Postdoctoral Research Associate to join a highly collaborative research program focused on RNA therapeutics, targeted drug delivery, extracellular vesicle
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accessibility and gene activity, using advanced genomics approaches such as CUT&Tag and RNA-seq, we can uncover how disrupted gene control leads to neurodevelopmental disorders including intellectual disability
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mass spectrometry data, RNA sequencing, or imaging. The candidate should also have a background in working with hierarchical data and resolving ambiguous, overlapping signals. Strong programming skills
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suggesting candidate mechanisms of resistance. The project will combine complementary models and techniques, including co-transplantation of organoids in mouse models, in vivo CRISPR, single-cell RNA
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laboratory experience, such as: DNA/RNA extraction, PCR, cloning, virus production, ELISA, etc. Computational biology laboratory experience, such as: bulk- singl cell- or spatial-transcriptomic data analysis
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Primary Supervisor: Dr Ke Li Foundation models trained on DNA and RNA sequences are beginning to transform genomics, but their predictions often remain difficult to interpret. A model may identify a
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. eLife (2019). PMID: 31042147 Wang G, Moffitt JR, Zhuang X. Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy. Sci Rep 8, 4847 (2018). PMID: 29555914 Moffitt JR
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in vitro model. The recruited PhD student will contribute to the three research axes of the project: - Single-nuclei RNA sequencing (snRNAseq) of microdissected arterioles from children with normal