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precision oncology through two interconnected areas: Understanding the biological mechanisms of cancer progression and therapeutic resistance: We integrate diverse molecular and clinical data modalities
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, multidisciplinary, and multi-omic approaches to elucidate the molecular mechanisms driving pediatric brain tumor therapeutic resistance and tumor-immune interactions. We aim to translate these discoveries into more
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screening and profiling efforts, including analysis of large patient cohorts and/or functional assays, to identify mechanisms of disease progression and treatment resistance. • Perform bioinformatic
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to identify new strategies to enhance their anti-tumor activity. Mechanisms of tumor immune evasion. Tumors employ diverse mechanisms to escape immune surveillance and resist immunotherapy. Using high
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, progression, and therapeutic resistance. Validate novel biomarkers and therapeutic targets through in vitro and in vivo studies. Contribute to translational research efforts bridging laboratory discoveries
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Instituto de Investigação e Inovação em Saúde da Universidade do Porto (i3S) | Portugal | 2 months ago
higher education institution, within the project “DISCLOSURE – Displaying the Gastric Cancer Glycome to Dissect Molecular Resistance to ErbB2-Targeted Therapy”, ref. - 2024.16350.PEX, financed by national
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the evolution of resistance or other life-history shifts in crop pests, and what determines the magnitude of these responses. The project therefore connects fundamental questions about genetic variation and
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. The application takes ten minutes to begin: your CV, and a few sentences on the problem you would start with. The full one-page proposal — why it has resisted solution, what its solution would make possible — can
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the School of Pharmacy at the University of Otago, located in beautiful Ōtepoti / Dunedin, New Zealand. Mō mātou | About us The Pletzer Laboratory investigates antimicrobial resistance, bacterial pathogenesis
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growth, metastasis and resistance to therapies. Stressed endoplasmic reticulum is cleared by a pathway known as "ER-phagy", yet it remains unclear how ER-phagy dysregulation contributes to cancer