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diseases, including Alzheimer’s disease, frontotemporal dementia and ALS, as well as other brain disorders such as multiple sclerosis. The department works closely with the Netherlands Brain Bank, providing
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consortium. Your academic supervision will be provided by Prof. Timo De Groof and Prof. Nick Devoogdt. This doctoral project focuses on developing GPRC5B-targeting nanobodies for use as research tools
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provided by Prof Kleopa Kleopa and Dr Irene Sargiannidou from the Neuroscience Department. PhD project This doctoral project focuses on establishing isogenic iPSC-derived myelinating organoids as a
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organisation is Amsterdam UMC, in the Netherlands. You will be employed by Amsterdam UMC and embedded in the POLARIS consortium. Academic supervision and disease-specific expertise will be provided by Dr Niek
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metabolomics, lipidomics, proteomics and genomics, and combine these data using statistical and machine-learning approaches. Established markers such as neurofilament light chain (NfL) and GFAP will provide a
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secondments will provide hands-on experience in in vitro assay validation and in vivo characterisation of lead molecules. You will use molecular receptor pharmacology techniques to investigate the orphan GPCR
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, the Netherlands. You will be employed by InnoSer and embedded in the POLARIS consortium, with academic supervision and disease-specific expertise provided by Dr Rogier Min at the Amsterdam Leukodystrophy Center
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will also undertake secondments. These will provide hands-on experience in regulatory science and orphan-drug analysis at Amsterdam UMC platform Medicijn voor de Maatschappij, as well as experience with
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provided by Dr Noémie Hamilton at the York Biomedical Research Institute and the Department of Biology at the University of York. You will focus on developing and standardising robust preclinical outcome
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machine-learning approaches. Established markers such as neurofilament light chain (NfL) and GFAP will provide a biological reference point for identifying disease-specific biomarkers. A central part of the