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Field
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join the eHACS project, and contribute to the experimental evaluation of the designed compounds for activity against their targets (FabF, PanK, and NMT) and to determine crystal structures of protein
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the body. The brain, immune system, cardiovascular system, liver, and other organs age at different rates. Because circulating proteins reflect the physiological states of multiple organs and cell types
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, particularly in molecular and cellular mechanisms of Parkinson’s disease (PD). Genetic studies have recently identified several PD-linked proteins that are involved in endocytic trafficking at the synapse
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Lewis Lab in the Department of Chemistry at Indiana University is accepting applications for a Postdoctoral Fellow position. The position offers an opportunity to develop and apply cutting- edge protein
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target novel mechanisms to mitigate aging-associated protein misfolding. Our current main focus is to study the human AMPylase, FICD, in the context of distinct protein misfolding diseases. For more
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maintenance, generating stable cells lines, primary neuronal cultures, stem cells including iPSCs); transfection in cellular studies; molecular cloning; RNA, DNA, and protein extraction and analysis (PCR, RT
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Completion of a PhD in Biochemistry, Protein Engineering, Neuroscience or any relevant discipline. Demonstrated experience in protein chemistry, recombinant protein expression and cell culture. Demonstrated
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. The successful candidate should have extensive experience from experimental laboratory work in molecular cell biology using techniques such as cell culture, CRISPR/Cas9 based genome editing, protein expression and
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-molecule biophysics. Funded by NSERC and CIHR, our research group investigates the mechanical properties, folding pathways, and conformational dynamics of proteins using advanced force spectroscopy
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/Protein isolation and analysis, histology, immunofluorescence/ immunohistochemistry, microscopy and quantitative and qualitative image analyses. -Strong organizational, analytical, communication, scientific