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. We employ intermediate and high-throughput molecular profiling platforms to interrogate the blood and tumors of patients receiving immunotherapy. The specific project will be tailored to the
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intermediate and high throughput molecular profiling platforms to interrogate the blood and tumors of patients receiving immunotherapy, including cutting-edge spatial transcriptomic platforms. With the
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perturbation and screening, mRNA therapeutics and vaccines, protein engineering, systems immunology, and tumor microenvironment profiling using single-cell and high-dimensional approaches. We are looking for
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systems, single-nucleus multiome (RNA and ATAC) and spatial profiling, and validation in human early-stage lung adenocarcinoma specimens. The position is supported by NIH funding and sits within a rich
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, base/prime editing, and targeted epigenetic modulation). Functional genomics in neuronal systems, including transcriptomic and epigenomic profiling. Model systems such as human iPSC-derived neural
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imaging, confocal microscopy, (single cell) RNA sequencing, chromatin profiling, and computational analysis. For more information on the lab, see our website: www.vanwolfswinkellab.org (Link is
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hybridization Neonatal stereotaxic surgery Whole-brain circuit and neuron-specific perturbation using viral strategies Fiber photometry Ribosome profiling Quantitative Real-time PCR Behavioral assays
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-omic profiling (small and long RNA-seq, lipidomics) to define exosomal cargo signatures associated with different disease states. · Develop and validate exosome-based biomarkers for treatment responses
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mouse models, in vivo two-photon structural and functional imaging with calcium indicators, chemogenetics, viral and transgenic tools, behavior, and molecular profiling to link circuit activity to
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(Link is external) and Yaari (Link is external) labs at Yale School of Medicine are seeking a highly motivated researcher to develop computational methods for multiomic immune profiling, with an