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Field
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involve manipulation of epigenetic marks in embryonic stem cells, investigating changes in epigenetic landscapes and transcription upon controlled manipulation, and/or engineering of synthetic chromatin
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to extend recent findings on rejuvenating aged immune systems through stem cell modulation (Ross et al., Nature 2024 (link is external) ). The successful candidate will work on projects investigating
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screening, next-generation sequencing, or bioinformatics. Experience in cell culture of primary and stem cells. Preference for experience with iPSCs and organoids. Knowledge of principles and practice
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and how alloimmunity is suppressed in patients receiving donor hematopoietic stem cells. In addition, the lab is using novel, spatial omics approaches to more comprehensively understand transplant
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hematopoietic stem cells. In addition, the lab is using novel, spatial omics approaches to more comprehensively understand transplant pathology. The main goal is to identify and validate novel biomarkers
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; Jacob et al., Cell Stem Cell 2022; Di Carlo et al., Nature Immunology 2023). Building on these findings, we aim at identifying novel mechanisms regulating the tumor microenvironment and antitumor immunity
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research and to drive in vitro drug target and mechanistic discovery efforts using 3D triple culture system based on iPSCs. The cell lines will be derived from participants of the Flemish Cognitive Compass
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research and to drive in vitro drug target and mechanistic discovery efforts using 3D triple culture system based on iPSCs. The cell lines will be derived from participants of the Flemish Cognitive Compass
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investigating tertiary lymphoid structures in inflammatory diseases, interorgan endocrine signaling, the comparative niches of stem cells across tissues, or mechanisms of transcriptional regulation such as
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cardiovascular disease. The lab uses patient‑derived induced pluripotent stem cells (iPSCs) from healthy individuals and patients with cardiovascular conditions to study GPCR function, single‑molecule movement