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and pooling, bioinformatics); and (5) validated measurement results and critically curated reference data shared with the community. Much of this effort will require close collaboration with academic
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Description Electromagnetic techniques can provide a means for rapidly analyzing or processing biochemical samples in a manner that can be readily scaled up to handle large numbers of samples in massively
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process via cell banks, raw materials, or the environment. These adventitious agents can potentially cause harm to recipients. Current testing methods are very time consuming and may not detect all types
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975 8997 Description Metabolomics can provide insight into many cellular processes. Metabolomic profiles of biological fluids (plasma/serum, urine, etc.) or bioprocess samples (mammalian cell lines
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processes of the organism at a given time and enables a characterization of the range of health parameters one would expect in changing environments. By probing the health status of a myriad of species, we
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independent strategies (metagenomics, bioinformatics, synthetic biology) to determine microbial function from sequence data. Since this project is highly interdisciplinary, we are seeking applicants from
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less). To address this technological bottleneck, we are developing a new technology platform--next gen protein sequencing--based on large-scale, massively parallel, single-molecule peptide sequencing
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bioanalytical chemistry, and bioinformatic data analysis. We invite applicants from diverse backgrounds, and successful applicants should expect to collaborate closely across an interdisciplinary team. Microbiome
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molecular motors and RNA-folding. In a parallel effort, we significantly enhanced the biophysical capabilities of an atomic force microscope (AFM). Specifically, we achieved sub-pN force precision and
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practices for benchmarking germline small-variant calls in human genomes. Nature Biotechnology 2019, 37, 555. Genomics; Bioinformatics; DNA sequencing; De novo assembly; Machine learning; Reference materials