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therapies before transplantation. In this PhD project, you will develop and evaluate innovative strategies to detect, prevent, and repair oxidative stress–associated injury in high-risk donor livers
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changes in all the cell types involved will also be investigated in depth, focusing on energy production and mitochondrial oxidative stress. Characterization will be carried out using omics analyses
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characterization of novel compounds, followed by their biological evaluation to identify selective NOX inhibitors as potential therapeutic agents for oxidative stress-related diseases. Where to apply Website https
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Essential: C1 Specialist research skills relevant to mitochondrial physiology, genetics/genomics, respirometry, metabolic physiology, ROS/oxidative stress, molecular biology or related experimental
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cardiovascular risk factors, including air pollution and gut microbes as well as inflammatory bowel diseases, cardiovascular function and disease development, and related mechanisms, especially oxidative stress
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on qualifications and interview Where to apply Website https://diogene.uniupo.it/public Requirements Additional Information Eligibility criteria Eligible destination country/ies for fellows: Italy Eligibility
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exposed to metabolic and oxidative stress. We have shown that supplementing these essential protective factors can significantly prolong cell survival in laboratory settings. This project aims to develop a
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ultrastructural assays to assess: Oxidative stress and mitochondrial function Lysosomal/autophagy flux and waste disposal Inflammatory signalling and complement activation Cell survival, death pathways, and barrier
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quantifying inclusion size and morphology and assessing the influence of surface features such as oxides, wire marks, and indents on stress concentrations. These data will inform numerical and analytical models
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organisms and plant organisms exposed in situ. Biomarkers of oxidative stress, elemental accumulation, and metabolic alterations will be analyzed to clarify the mechanisms linking PM composition and sources