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emerging from other POLARIS work packages. By aligning preclinical readouts with clinically relevant endpoints, your work will contribute to the translational value of leukodystrophy models. You will work
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embedded within the Quantitative Healthcare Analysis (qurAI) group and conducted in close collaboration with the CARA Lab and clinical partners in the Netherlands and abroad. You will work with large, multi
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in the POLARIS consortium and work with experts in leukodystrophy, paediatric neurology, developmental psychopathology, resilience research and digital quality-of-life assessment. Leukodystrophies can
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through to preclinical characterisation. Your work will include: Selecting GPRC5B-targeting nanobodies from immune and synthetic nanobody libraries and evaluating AI-generated candidates. Characterising
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pursue a PhD degree in a relevant discipline. You will contribute to the development and validation of liquid biomarkers for leukodystrophies. You will work with iPSC-derived disease models and patient
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partners in the Netherlands and abroad. You will work with large, multi-center clinical datasets and contribute to translating advanced computational methods into clinically relevant applications. This PhD
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. Your work includes: establishing and using isogenic iPSC-derived myelinating organoids as a human in vitro disease model; testing AAV variants and assessing their effects on myelination and
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Hospital Tübingen (Eberhard Karls University of Tübingen), Germany. You will be embedded in the POLARIS consortium and work with experts in leukodystrophy, paediatric neurology, developmental psychopathology
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of liquid biomarkers for leukodystrophies. You will work with iPSC-derived disease models and patient samples, generate and analyse multi-omics data, and help identify biomarkers that can support diagnosis
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to simulate colonization resistance and ARG transmission dynamics, guiding the design of microbiome-based interventions. Collectively, this work will clarify the role of E. coli in infant gut ecology, support