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sequence the complete DNA of babies at birth to screen for hundreds of genetic conditions. This PhD project will generate the evidence to inform which genes and variants should be included in newborn genome
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research team of Dr Sarra Ryan in the use of ultra-long-reads and hybrid sequencing approaches to explore highly repetitive DNA sequence in relation to genomic instability in childhood cancer. Highly
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, CRISPR-Cas9, single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (RNA-seq), multispectral imaging, immunohistochemistry, Western blotting, tissue culture, genotyping, and qPCR. Under
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and biological mechanisms underlying bleeding phenotypes by integrating whole-genome sequencing with functional studies in individual patients and affected families. In parallel, the project focuses
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that can influence this efficiency. This project aligns with the priority of sustainable development and the University of Newcastle’s strategic plan to further support next generation resources and growing
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flexibility as well as a strong motivation to address this challenge using multiple lines of evidence. Tasks and responsibilities: Co-designing and conducting field sampling and measurements, lab experiments
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and oral English communication skills Willingness to work with wild rodents and in the field Expertise with next generation sequencing data and associated bioinformatics Preferences Preferred
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About the position The exact tasks will depend on the skillset of the researcher and desired employment duration, but will include anaerobic cultivation of bacteria, single cell RNA sequencing, and
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. Experience working with geospatial data and spatial analysis, or the ability to learn. Experience analysing whole genome libraries, including quality control, sequence alignment, and calculating population
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of genomics such as genome sequencing and single cell approaches, in addition to broader data integration efforts across multiple types of 'omics data. The advertised role provides analytical support in