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, functional and metabolic analyses, and co-culture models with tumour microenvironment cells. In vivo experiments using orthotopic mouse models will enable the study of their role in tumour formation and
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. The PhD candidate will investigate the links between inflammatory signaling, cellular stress responses, senescence, and the maintenance of HSC function. The project will combine mouse models with cellular
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; Birnbaum et al. 2012). Recent work has revealed that human and mouse genomes harbour thousands of protein-coding exons with strong transcription factor binding signals and enhancer-like chromatin signatures
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platform for large-volume 3D microscopy of ex vivo mouse tissue, called chromatic multiphoton serial microscopy (ChroMS) (Abdeladim 2019, doi.org/10.1038/s41467-019-09552-9; Blanc 2023, doi.org/10.1021
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and cellular functions. This project will combine complementary approaches in cellular neurobiology, molecular biochemistry, and developmental biology, using primary cultures of mouse neurons and cell
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activate spinal networks. This PhD project aims to investigate the underlying mechanisms of rSynES-induced recovery using a mouse model of cervical SCI, through longitudinal assessment of molecular and