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cellular biology approaches. The Park Lab develops human stem cell-based neural models to investigate molecular and cellular mechanisms regulating neurodevelopment and neural function, and to understand how
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communication, and functional adaptation across a wide range of disease-relevant systems. The successful candidate will use enhanced-sampling molecular dynamics, coarse-grained elastic network models, Markov
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mouse models. Experience studying the hypothalamus or neural regulation of metabolism. Experience with neural tracing techniques. Experience performing stereotaxic surgery in mice. Excellent
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following: - Mouse models, mouse breeding, and animal surgery - Histology and immunohistochemistry - Cell culture and stem cell biology - Molecular biology techniques (PCR, cloning, Western blotting) - Flow
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drug-discovery and small-molecule screening assays using keratinocyte and epithelial model systems. • Establish, optimize, and troubleshoot cellular, molecular, biochemical, and imaging-based
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-based perturbations, base/prime editing, and targeted epigenetic modulation). Functional genomics in neuronal systems, including transcriptomic and epigenomic profiling. Model systems such as human iPSC
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robust, open-source implementations and connect the resulting models to nonadiabatic molecular dynamics simulation workflows. We’re here for the same mission, to bring science solutions to the world. Join
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-injection, recovery and analysis of mutants, the other more molecular biology-focused, related to development and adaptation of prime editors, especially with variant PAM sites and other molecular aspects
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qualifications: Experience with molecular modeling and/or structure-based drug design Salary: Commensurate with experience How to apply: Interested applicants apply online at https://slu.wd5.myworkdayjobs.com
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mouse models. The research will include colony management and genotyping, deployment and evaluation of in vivo gene therapy treatments, EEG and behavioral assessments, histology and molecular studies