7 molecular-modeling positions at Institute of Bioorganic Chemistry Polish Academy of Sciences in Poland
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affecting CAG repeat instability (genetic context and cell type) and (4) controlled shortening of CAG repeats in a Huntington's disease mouse model. ICHB PAN is one of the leading research units in Poland and
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effects of these dietary regimes by utilizing relevant knock-in mouse models for SCA3 and cutting-edge multi-omic, molecular, epigenetic, and behavioral methodologies. Our goal is to provide evidence-based
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ataxin-3 protein, preventing altered cellular processes that result in neurodegeneration in the brain cells of model animals. Our preclinical study using the SCA3 mouse model will test the small molecular
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22 Apr 2024 Job Information Organisation/Company Institute of Bioorganic Chemistry Polish Academy of Sciences Department Department of Molecular and Systems Biology Research Field Biological
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datasets from different stages of neurodegeneration in AD will enable the development of an in silico model of neurodegeneration that will be further validated in human neuronal progenitors. Using RNA-based
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model cell lines, surgical isolates, and methods of molecular and cellular biology, biochemistry, transcriptomics, and proteomics. The current project aims at investigation of routes of RNA metabolism
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program, (3) chemical mapping of two large fragments of the 28S subunit of the human ribosomal RNA (rRNA). Both model rRNAs contain 5 and 13 pseudouridine residues, respectively. They are selected from