Senior Scientist, In Vitro Pharmacology, Neuroinflammation

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

The Pfizer Inflammation & Immunology Research Unit (I&I RU) in Cambridge is seeking a motivated and dynamic Senior Scientist to join the In Vitro Pharmacology Group. The main responsibilities of the candidate scientist are to develop, execute and provide pharmacology expertise for in vitro model systems and assays of neuroinflammation and neurodegenerative diseases, and to conduct and support mechanistic in vitro and ex vivo studies. This candidate will also carry out in vitro experiments to support the identification and characterization of lead molecules to successfully deliver on our neuroinflammation portfolio. The ideal candidate will demonstrate close attention to detail, effective reasoning, and discipline-specific problem-solving competencies in experimental design.

How You Will Achieve It

• Support the growth of neuroinflammation and neurodegeneration capabilities by designing and executing preclinical in vitro studies and guiding strategic vision for our neuroinflammation portfolio. This includes the establishment and optimization of new in vitro assay systems and implementation of disease relevant endpoint measurements.
  
• Stay up to date with literature, competitive landscape and follow new trends/innovations with in vitro technologies in the neurodegeneration/neuroinflammation space.
  
• Collaborate with RU scientists and other partner lines across Pfizer to support drug development and deliver on portfolio project needs.
  
• Utilize available resources to achieve timely execution of projects and collaborate with cross-functional teams (internal and external) to execute plans and deliverables.
  
• Regularly record experimental work upon completion in electronic notebook systems.
  
• Analyze, interpret, upload and present data in project team meetings and Department meetings.
  
• Serve as a resource to explore new avenues for preclinical research in neurodegeneration.
  
• Educate other scientists, provide hands-on training, and give internal and external presentations.
  

Qualifications

Must-Have

• PhD in Biology, Neuroinflammation, Neuroscience or other related discipline with 0-3 years of experience or MS with 5+ years of relevant molecular and cellular biology experience or bachelor's degree with 6+ years of relevant molecular and cellular biology experience.
  
• Extensive hands-on lab experience in neuroscience or neuroinflammation disciplines.
  
• Experience in and working knowledge of biopharmaceutical research and drug discovery.
  
• Excellent communication and analysis skills: ability to compute complex information to conclusion and provide data driven recommendations.
  
• Decision- and action-oriented, with high level of autonomy.
  

Nice-to-Have

• Hands-on expertise with primary neural cell culture techniques and in vitro differentiation from progenitor cells to support pharmacology studies.
  
• Experience assessing neurodegenerative disease relevant endpoints using in vitro cell culture systems, neuronal co-culture experience is a plus.
  
• Proficiency in a variety of state-of-the-art imaging techniques (e.g., high content imaging, confocal microscopy).
  
• Peer-reviewed and quality publications in neuroinflammation/neurodegeneration.
  

P hysical Requirements:

• lifting, sitting, standing, walking, bending
  

Other Job Details

• Work Location Assignment:On Premise
  

The annual base salary for this position ranges from $85,700.00 to $142,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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