Senior Associate Scientist

Pfizer's BioMedicine Design (BMD) High-Throughput Protein Production (HTP) group is seeking a highly motivated scientist to manage and perform antibody expression and purification, from hundreds to thousands of proteins per week. The candidate will play a critical role in production and automation process innovation in a core group that is responsible for high-throughput cloning, expression & purification of antibodies (microgram-to-milligram scale).

The candidate will be part of a team responsible for high throughput automated transfection, purification, quantitation, analytical assessment, and normalization/delivery of protein samples, including conventional antibodies, bispecifics, and occasional non-antibody proteins; data upload in the departmental database/ELNs; and interacting with project teams. The candidate will contribute to group-wide deliverables, work on several projects simultaneously, explore new purification technologies, and present results and updates at group, project, and departmental meetings.

How You Will Achieve It

• High-throughput automated antibody purification, quantitation, analytical SEC, normalization, and redox for bispecific antibody generation utilizing the team's liquid handling automation equipment.
  
• Optimization of automated processes throughout the HTP workflow
  
• Maintaining mammalian cell stocks, transfecting and harvesting conditioned medium in small- and micro-scale.
  
• Managing the purification database, scheduling purifications, and delivering custom arrayed materials to downstream users
  
• Maintaining & troubleshooting of liquid handlers
  
• Development of automated bispecific antibody generation methods using different antibody formats
  
• Close interaction with protein engineering project teams to plan and coordinate protein production
  
• Presentation of purification data at group & project team meetings
  
• Regular review of literature to m aintain knowledge of scientific trends and industry processes, advance molecular biology and protein production methods
  

Qualifications

Must-Have

• Bachelor's degree & 2-4 years of experience, or master's degree and 1-2 years of experience, in protein purification, biochemistry, biology, chemical engineering or a related discipline, along with a basic understanding of antibodies and protein production.
  
• Demonstrated technical proficiency in protein purification
  
• At least 2 years of experience with using laboratory automation, including writing and troubleshooting protocols
  
• Track record of strong problem solving and organizational skills, orientation to detail
  
• A bility to multi-task, prioritize responsibilities, work under strict deadlines, and remain flexible with changing needs
  
• Ability to work effectively to solve process development problems and implement improved procedures.
  
• Strong written and oral communication skills
  

Nice-to-Have

• Experience with Tecan, Beckman, and/or Lynx liquid handling platforms
  
• Industry experience in protein expression/purification/antibodies/ molecular biology
  
• Experience with high throughput sample tracking and laboratory logistics software
  
• Experience in writing and understanding methods for laboratory automation technologies.
  

PHYSICAL/MENTAL REQUIREMENTS

• Lifting, sitting, standing, walking, bending, reaching, ability to perform mathematical calculations and ability to perform complex data analysis.
  

Other Job Details:

• Last Day of application: February 9th, 2023
• Work Location Assignment:On Premise, colleagues work in a Pfizer site because it's needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.

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Relocation assistance may be available based on business needs and/or eligibility.

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Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

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Research and Development