POSITION OBJECTIVE
Working under moderate supervision, the Research Assistant 1 will perform research work and support scientists in understanding how genetic variation and environmental exposure (gut-brain-axis) predispose to neurodegenerative disorders including Frontotemporal dementia (FTD), Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD). This individual will perform technical procedures and experiments according to specific instructions/protocols including flow cytometry, immunoblot, ELISA, qRT-PCR, and microscopy collected with aid by supervising staff as well as analyze large single cell transcriptomic using R coding environment and associated packages. Data will be collected and recorded in laboratory computers for statistical analyses and the research assistant will contribute to the generation of data figures for grant submissions and publication of manuscripts, as well as present data at group meetings. This individual will pro-actively follow their job duties while adhering to and ensuring ethical compliance with all legal regulations. They will also ensure strict adherence to all safety guidelines while dealing with hazardous substances, animal subject- and human subject-derived materials in the lab and will have the physical stamina and endurance to perform all associated tasks. This position will work with animals.
ESSENTIAL FUNCTIONS
NONESSENTIAL FUNCTIONS
Perform other duties as assigned (4%)
CONTACTS
Department: Daily contact with supervisor to discuss research and maintain workflow
University: Occasional contact with other departments to share information and help enable collaborations. Limited interaction with regulatory components (IACUC, IBC, IRB)
External: Occasional contact with vendors to procure supplies
Students: Occasional contact with student employees to explain policies and procedures and ensure proper adherence to all legal, health and safety standards
SUPERVISORY RESPONSIBILITY
This position has no direct supervision of staff employees.
QUALIFICATIONS
Experience: Bachelor’s degree in science and 0 to 1 year of related experience or Associate’s degree in an approved biotechnology program and 0 to 2 years of relevant experience.
REQUIRED SKILLS
WORKING CONDITIONS
General laboratory environment. The employee is required to work with and handle research animals and may have exposure to hazards. The employee will need to wear appropriate protective equipment such as gloves, sleeves and lab coat. Working conditions will require working at the bench and tissue culture hood in a molecular genetics/neuroinflammation laboratory, working with mice in the laboratory and in the animal facility, and when needed working outside standard working days or hours as required by the needs of a given experiment.
Case Western Reserve University’s animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the “Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals.” This position, and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
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Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.
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