Postdoctoral Fellow in Bioengineering (Stem Cell Research)

Harvard University, United States

Updated: almost 2 years ago
Location: Cambridge, MASSACHUSETTS
Deadline: ;

Details


Title Postdoctoral Fellow in Bioengineering (Stem Cell Research)
School Harvard John A. Paulson School of Engineering and Applied Sciences
Department/Area Bioengineering
Position Description
The Liu group at the School of Engineering and Applied Sciences (SEAS) at Harvard is looking for a well-qualified and energetic postdoctoral fellow working on developing and applying bioelectronics and spatial-omics tools to understand human stem cell-derived organoid development and maturation for stem cell therapy. We are developing a cyborg organoid technique, which implanted and distributed stretchable nanoelectronics across entire organoid bodies through 2D-to-3D organogenesis triggered by cell-cell interactions, enabling long-term stable, organoid-wide, 3D multimodal recordings at single-cell resolution throughout stem cell and tissue development and maturation with minimal impact on growth and differentiation (Nano Letters 2019 and Advanced Materials 2022). We are also combining cyborg organoids with tissue clearing and in situ single-cell RNA sequencing, which can integrate a cell’s electrical activity recording with its gene expression, assessing the functional and transcriptional maturation of the human cardiac, brain, and pancreatic organoids for stem cell therapy.
 
This postdoctoral position will provide an exciting opportunity to develop new experimental and computational methods to integrate bioelectronics with spatial-omics in a vibrant and interdisciplinary environment and collaborate with team members from diverse backgrounds (chemistry, biophysics, genomics and neuroscience, electrical engineering and computer science, and bioengineering). 
 
Beyond our lab, this position will also offer collaboration opportunities with other experimental and computational teams (genomics, data science, machine learning) at the Broad Institute of MIT and Harvard and Harvard Stem Cell Institute. We emphasize research training and career development for all lab members, and the candidate will have the chance to interact with the broader community at Harvard, MIT, the Broad Institute and the Harvard-affiliated hospitals across Boston.
 
Basic Qualifications
A PhD in Biomedical Engineering, Bioengineering, or Biology
Additional Qualifications
Significant pluripotent stem cell culture experience. 
Extensive experience in stem cell 3D culture and differentiation (neurons, cardiomyocytes, or pancreatic beta cells). 
Experience in single-cell RNA sequencing, bioimaging, electrophysiology or gene editing.
A strong quantitative analysis background.
Self-motivated, creative, persistent, responsible, good analytical and problem-solving skills. 
 Candidate with ONE or MORE of the following areas will be given priority:
- Single-cell genomics and/or transcriptomics
- Electrophysiology and neuroscience
- Bioimaging
Special Instructions
Cover letter
CV
3 references
3 representative papers
Any listing of a public code repository (e.g. Github)
SEAS is dedicated to building a diverse and welcoming community, and we strongly encourage applications from historically underrepresented groups.
Contact Information
Jane Salant
150 Western Avenue
Harvard University, SEC Room 2.401
Boston, MA  02134
Contact Email [email protected]
Equal Opportunity Employer
Harvard is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, sex, gender identity, sexual orientation, religion, creed, national origin, ancestry, age, protected veteran status, disability, genetic information, military service, pregnancy and pregnancy-related conditions, or other protected status.
Minimum Number of References Required 3
Maximum Number of References Allowed
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