Research Associate IMAXT lab (Fixed Term)

The IMAXT laboratory at the CRUK Cambridge Institute (part of the University of Cambridge) is seeking to hire a talented and motivated Research Associate to collaboratively realise the vision of the IMAXT project, a large international consortium employing cutting-edge technologies to produce molecularly annotated 3D models of cancer at single cell resolution. A core objective of the project is to provide a better way to understand tumor heterogeneity and how it influences metastasis and response to cancer therapy. The successful applicant will join the IMAXT laboratory and will focus on the study of the process of vasculogenic mimicry and its role in cancer development, progression and evasion of therapeutic pressure.

We are looking to recruit an enthusiastic, creative and highly competent individual with relevant experience in cancer biology. Experience in animal models of cancer, especially patient-derived models, and their use to study angiogenesis and/or vasculogneic mimicry would be highly desirable. The role holder for this position will be responsible for probing mechanisms of vasculogenic mimicry in faithful syngeneic and xenograft models of human cancers, with a particular focus on breast, lung, and renal.  Experience in these cancers is also highly desirable. 

These models will be used to investigate the role of the micro-environment and of tumour heterogeneity in cancer progression and response to therapy. In addition, the role holder will contribute to the development of a series of novel analytical techniques to measure the proteome and transcriptome of tumour samples in situ on histological specimens, and their application to produce 3D molecularly annotated model of tumours and investigate the questions described above.

The role holder will be expected to have significant experience and skills in small animal models of cancer, cell biology techniques (cell culture, transfection/transduction, flow cytometry) and histology (immunohistochemistry, in-situ hybridization).

The successful candidate should show initiative and independent thinking, possess excellent communication skills and work effectively as part of a team.

Applicants should have a PhD in a relevant discipline.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a basic disclosure (criminal records check) check, a health assessment and a security check.

We welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

To apply online for this vacancy and to view further information about the role, please visit :

http://www.jobs.cam.ac.uk/job/32461 .

Closing date: 6th January 2022

Interviews: TBC

Please send applications in the following format: a CV; a publication record if available; a cover letter explaining why you wish to be considered for this particular role, what you will bring to the project and listing your research experience to date.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £30,497) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please quote reference SW29088 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.