Postdoctoral Fellow - Cell Cultures

The Opportunity:

The Jones group are seeking a Postdoctoral Fellow to decipher how oncogenic mutations colonise normal human tissues. You will work at the leading edge of experimental functional genetics exploiting a new 3D culture epithelial system together with confocal live imaging and CRISPR-Cas9 technologies to study mutant cell competition and how it is influenced by environmental factors on it. The goal of the project is to find interventions that can deplete mutant cells from normal tissues.

 About Us:

The Jones lab are world-leaders in studying how oncogenic mutants spread through normal tissues in the earliest stages of cancer development ( 1, 2, 3 , 4 ) with pioneering studies on how such mutations affect stem cell behaviour. Our approach is to work in a multidisciplinary and collaborative manner, with a team of wet-lab experimental and data scientists who work closely to generate and analyse biological datasets that range from live imaging or single cell sequencing to whole genome screens. Our combined expertise in DNA sequencing, in vivo lineage tracing, advanced 3D cell cultures and CRISPR based gene-editing puts us in the ideal position to develop novel interventions to prevent cancer.

About You:

You should have a PhD in cancer, functional genetics or cell biology, be highly experienced in cell culture techniques and microscopy and, ideally, have experience using CRISPR gene editing and running informatics packages. You should enjoy using innovative technologies to achieve their research goals and publish the results. You should have a proven track record of innovation and productivity, be a very collaborative team player, have excellent organizational skills, and strong verbal and written communications skills.

Technical:

• PhD in cancer biology, cell biology, molecular biology, genetics or related discipline 
• A diverse range of research experiences and technical skills in experimental molecular/cellular biology, including molecular cloning, lentiviral production, flow cytometry and advanced mammalian cell culture. 
• Evidence of good productivity through publications 

Behaviours and Competencies:

• Excellent communication, organisational and presentation skills 
• Excellent problem solving and troubleshooting skills 
• Ability to work independently and organize own workload 
• Ability to organize, plan and prioritize tasks or projects 
• Demonstrate good networking, influencing and relationship building skills 
• Ability to communicate ideas and results effectively 
• Demonstrates inclusivity and respect for all 
• Ability to build collaborative working relationships with internal and external stakeholders 

• Experience advanced primary cell culture 
• Experience 3D and live imaging 
• Experience modelling cell-cell interactions 
• Knowledge of statistics 
• Knowledge of R or Python applied to image and data analysis. 

When you join us as a Postdoctoral Fellow , you will benefit from a unique learning environment. We are proud to produce and analyse genetic and biological data on a scale unmatched by other institutes in Europe.

We pride ourselves in offering a first-class and well-resourced exceptional learning environment to equip individuals with the knowledge and skills they will need for a successful career in science.

 Application Process:

Please apply with your CV and a cover letter outlining your suitability for the role addressing the criteria set out above and in the job description.

Interviews will be held on 7th, 9th and 10th September 2021.