Postdoc Position in Human Organoid-Based High-Throughput Systems for Anti-Infective Drug Discovery

EPFL, the Swiss Federal Institute of Technology in Lausanne, is one of the most dynamic university campuses in Europe and ranks among the top 20 universities worldwide. The EPFL employs more than 6,500 people supporting the three main missions of the institution: education, research and innovation. The EPFL campus offers an exceptional working environment at the heart of a community of more than 17,000 people, including over 12,500 students and 4,000 researchers from more than 120 different countries.

Your mission :
We are excited to announce an open postdoc position on a groundbreaking project focused on the development of novel organoid-based infection models for antimicrobial discovery. The project will be focused on increasing the throughput of human lung microtissue models our lab has developed to study the antibiotic resistant pathogen Pseudomonas aeruginosa . The postdoc will take advantage of state-of-the-art microfabrication, prototyping and bioprinting facilities available in the lab and at EPFL. This innovative project aims to revolutionize the discovery of new anti-infective drugs and to advance our understanding of the mechanisms underlying antimicrobial resistance. The project will include opportunities to interact with a clinical team developing novel phage therapies against resistant P. aeruginosa .

Main duties and responsibilities include :

• Design and engineering of high throughput human lung organoid infection models
• Data analysis and interpretation, with a strong emphasis on automated image processing.
• Application to screening of anti-infective compounds.
• Application to the investigation and characterization of antimicrobial resistance mechanisms using clinical samples.
• Collaboration with a multidisciplinary team of scientists and researchers to integrate findings into broader anti-infective drug discovery efforts. Collaborative projects will include screening for therapeutic phage for direct clinical applications and in silico drug development using advanced AI-based methods.

Your profile :

• PhD (or nearing completion of) in Bioengineering, Mechanical Engineering, Material Sciences or related field.
• Strong track record in tissue engineering, bioprinting, organoids and/or microfabrication for biological applications.
• Experience with microscopy, image analysis tools and standard coding skills.

Term of employment :
Fixed-term (CDD)

Contact :
To apply, please submit your application, including a CV, a cover letter, and contact information for three references.
For any question please contact : [email protected]
Application Deadline: April 29, 2024

Remark :
Only candidates who applied through EPFL website or our partner Jobup’s website will be considered. Files sent by agencies without a mandate will not be taken into account.

Reference :
Job Nb 3312

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