Post-doc positions in Medicinal Chemistry 100%

The Department of Biomedicine, University of Basel, Switzerland, invites qualified candidates to apply for post-doctoral positions in Medicinal Chemistry.The candidate will join a multi-disciplinary team focusing on the development of new bioactive molecules targeting major signaling pathways in cancer and inflammation. Main targets are stress kinases vital for metabolic control and immune checkpoint modulation in cancer therapy.
The working place of the successful candidate is the Department of Biomedicine at Mattenstrasse 28, 4057 Basel.
Ongoing projects:
i) role of PI3Kgamma complexes in allergy, metabolic control, obesity, diabetes and cancer.
https://p3.snf.ch/project-189065

ii) highly specific targeting of PI3Kalfa using novel chemical probes and degraders in cancer and metabolism, and dissection of mechanisms of adverse effects.
https://p3.snf.ch/project-204602

For a relevant recent publication see Borsari et al. (2022) J. Am. Chem. Soc. 144(14): 6326–6342
https://doi.org/10.1021/jacs.1c13568
The projects are funded by the Swiss National Science Foundation and the Swiss Cancer League (see links above for abstracts and more info).

• Design, development and implementation of multi-step syntheses to access small heterocyclic molecules with chemically reactive warheads to generate cancer targeting covalent inhibitors.
• Improve biological activity of hit compounds through structure-activity relationship (SAR) studies, and support preclinical development processes.
• Work in a multi-disciplinary environment (collaboration with biologists, organic chemists and computational chemists).
• Writing of scientific publications, patents and regulatory reports.

The successful candidate holds a PhD in organic or medicinal chemistry. Expertise in organic synthesis with emphasis on the synthesis of biologically active molecules is desired. The candidate has an excellent proven track record in the publication of peer-reviewed scientific articles and/or patents.
Candidate's Ph.D. should not be more than four to five years in the past.

University of Basel is an equal opportunity employer. Salaries are according to the staff-regulations and depend on the qualifications and experience of the candidate.
The position will be initially for one year with a possibility of extension of 2+ years based on performance. The candidate should also be able to acquire personal grants.

Application / Contact

Please submit your resume (CV), a letter of motivation, a putative career plan, diplomas, and addresses of 2-3 to UniBas recruitment platform at https://career2.successfactors.eu/sfcareer/jobreqcareer?jobId=4174&compa...

For project-related issues send inquires to Prof. M. Wymann via [email protected] (subject line "DBM-4/2022-MedChem").