The Department of Biomedicine, University of Basel, Switzerland, invites qualified candidates to apply for post-doctoral positions in Medicinal Chemistry.The candidate will join a multi-disciplinary team focusing on the development of new bioactive molecules targeting major signaling pathways in cancer and inflammation. Main targets are stress kinases vital for metabolic control and immune checkpoint modulation in cancer therapy.
The working place of the successful candidate is the Department of Biomedicine at Mattenstrasse 28, 4057 Basel.
Ongoing projects:
i) role of PI3Kgamma complexes in allergy, metabolic control, obesity, diabetes and cancer.
https://p3.snf.ch/project-189065
ii) highly specific targeting of PI3Kalfa using novel chemical probes and degraders in cancer and metabolism, and dissection of mechanisms of adverse effects.
https://p3.snf.ch/project-204602
For a relevant recent publication see Borsari et al. (2022) J. Am. Chem. Soc. 144(14): 6326–6342
https://doi.org/10.1021/jacs.1c13568
The projects are funded by the Swiss National Science Foundation and the Swiss Cancer League (see links above for abstracts and more info).
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