Post-Doc position in quantitative biology (Zampieri Lab)

Your position

The candidate will have the opportunity to exploit some of the cutting-edge experimental and computational methods, comprising constraint-based and kinetic modeling, statistical analysis of large datasets, high-throughput metabolomics, time-lapse microscopy, to investigate how to pharmacologically interfere with fundamental mechanisms in the regulation of bacterial metabolism. Available resources at the department include a mouse facility, high-end FACS, IT and microscopy facilities, the Life Sciences Training Facility (for gene expression and proteome profiling) and much more.

Your main tasks will be:

• Apply and develop model-based and statistical approaches to analyze and interpret large compendia of metabolome profiling of small molecules effects on bacteria.
• Adapting existing and developing improved experimental protocols for the high-throughput metabolomics analysis of drug-perturbed bacteria across different growth conditions.
• Unravel the hidden potential of apparently inactive molecules in hampering bacterial infection 
• Determining the underlying mechanisms that link antibacterial efficacy to the metabolic or physiological state of bacteria.
• Testing their relevance in host-like environmental conditions
• Support and preparation of scientific reports and journal articles