Laboratory Manager & Perfusionist (m/f)

Wyss Zurich
Laboratory Manager & Perfusionist (m/f)
100 %
The Wyss Zurich Translational Center (Wyss Zurich) is a joint accelerator of the ETH Zurich and the University of Zurich, which was made possible by a generous donation from the Swiss entrepreneur and philanthropist Dr. hc. mult. Hansjörg Wyss. The mission of Wyss Zurich is to drive the clinical translation and technology transfer of outstanding scientific discoveries into new therapies for patients and breakthrough innovations in the emerging fields of Regenerative Medicine and Robotics, and to promote hybrid technologies in these fields. Wyss Zurich brings together some of the world's leading experts to form multidisciplinary teams, pooling their knowledge and expertise.
You will be part of the Liver4Life project: Liver resection is the established treatment for primary and metastatic liver cancer. Unfortunately, 70% of these patients have a non-resectable liver due to the small size of the future liver remnant (FLR). Furthermore, shortage of donor organs results in many patients dying on the waiting list. The unique ability of the liver to regrow after a part of it has been surgically removed, the so-called liver regeneration, will be exploited in this project to develop urgently needed alternatives for the treatment of liver cancer and for a reduction of liver organ shortage. Two key ingredients are required for the proposed ex vivo regeneration technology – a perfusion machine and a perfusion protocol that triggers and maintains the liver growth. The machine is able to mimic a body-like environment and perfuse the resected or split liver in a close-to-physiological manner. The perfusion protocol defines dosage and timing of all infusions (nutrients, medications, hormones, growth factors) to the perfusate. In the scope of this project, we aim at developing a perfusion machine and protocol for patients with severe liver disease by bringing a unique technology to the clinic.
Your responsibilities

• Run biochemical and molecular biology assays in pig and human samples (luminescence, protein and RNA extractions, qPCR, western blots, ELISA etc).
• Perform analyses and interpret the results
• Document laboratory work procedures in a methodical manner and generate technical reports based on the experimental results
• Maintain stocks of laboratory materials, equipment, and chemicals
• Assist animal surgeries
• Assist perfusion experiments in a clean room environment (ETH)
• Manage infrastructure of the clean room (ETH)
• Clinical Trial responsabilities: Procurement process, support in Risk Management activities

Your profile

• You are a Biology Laboratory Technician, or have obtained a BSc/MSc in Biology, Biotechnology, or equivalent education
• We are looking for someone with excellent organization and communication skills, reliability, and the ability to easily adapt to different tasks
• Practical experience in basic cell and molecular biology techniques ideally with lab management experience.
• LTK1 and LTK20 modules are a plus
• Very good observation skills
• Ability to work both independently and within a team in a challenging environment
• Sense of responsibility, flexibility, and enthusiasm
• Good knowledge in the MS Office suite (Excel, Word, and PowerPoint)
• Good language skills in English and ideally German
• Applicants must be either Swiss citizens, EU-nationals or have the legal right to live and work in Switzerland

What we offer
We offer working in an innovative project in an energetic, dynamic and young team, exposure to a fascinating research field and cutting edge technology, and conditions of employment of the University of Zurich.
Place of work
Sternwartstrasse 14, Zürich, Switzerland
Start of employment
Employment start date is immediately or upon mutual agreement. Please submit your application by 30.06.2022.
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