Research assistant in naive stem cell biology and development

The Developmental and Translational Neurobiology research group, headed by Dr. Cristiana Cruceanu, studies molecular mechanisms of environmental exposures shaping early human development. The overarching aim is to understand the long-term outcomes of these exposures on neurodevelopmental disorders and mental health. We use state-of-the-art in-vitro cell culture models of the brain and placenta. The exposures at the forefront of our interest are stress hormones, psychotropic medications, and inflammatory agents, given their interconnected mechanisms of action and relevance in neuropsychiatric phenotypes. Our work aims to improve our understanding of prenatal exposures and inform treatment decisions for stress-related disorders among pregnant women with evidence about the likely outcomes in their developing children. The Cruceanu lab is part of the Department of Physiology and Pharmacology at Karolinska Institute, located at the Biomedicum, an interdisciplinary research center designed to concentrate the world-class experimental research conducted at Karolinska Institutet Campus Solna.

Lab website: https://ki.se/en/fyfa/developmental-and-translational-neurobiology

We are currently looking to recruit a Research Assistant to develop novel brain and placenta modelling systems that rely on naïve embryonic and induced pluripotent stem cells. These in-vitro tools will be used for exposure assays whereby we assess the impact of psychotropic medications and stress hormones on tissue development and function.

Suitable candidates must have significant experience working with embryonic and induced pluripotent stem cells, and ideally experience with naïve stem cell reprogramming, culture and manipulation. Experience with advanced cell culture systems like organoids, immunofluorescence protein labelling and confocal microscopy, as well as quantitative PCR and western blotting will be considered favourably. Successful applicants will have the opportunity to work in a stimulating and collaborative environment with state-of-the-art infrastructure.

Qualified to be employed as a research assistant is one who has obtained an MSc in molecular biology, neuroscience, psychology, pharmacology, or a related field.

Fluent written and spoken English is required. Above all, we will evaluate highly the ability of the candidate to work independently and creatively while also being a team player who can collaborate and contribute positively to various ongoing projects. The Cruceanu laboratory is strongly committed to equity, diversity, and inclusiveness, and individuals from diverse backgrounds are encouraged to apply.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At KI, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialties and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement. You get to practice freely in our modern wellness facilities, where trained staff are on site.

Location of position: Solna, Biomedicum

Welcome to apply at the latestmars 15:th. 

The application is to be submitted through the Varbi recruitment system. In this recruitment, you will apply with your CV an optional personal letter. You are also asked to answer some questions about why you are applying for the job in the application form. You will be asked to provide the contact information of two references.

Welcome to apply!