Postdoctoral Researcher on human reproduction and regenerative medicine

If you do, the Department of Women’s and Children’s Health is the place that you are looking for! Our department consists of six divisions with approximately forty research groups, conducting leading education and research with a global impact on women’s and children’s health. Research on human reproduction and regenerative medicine are core interests of our department, which vision aligns with Karolinska Institutet's mission of advancing medical knowledge through innovative basic research, in one of the world's leading hubs for medical research.

In this project, you will focus on the investigation of human primordial germ cell (hPGC) specification and early development, which occurs during early human embryonic development. To model and decipher the mechanisms behind hPGC early development, you will utilize human pluripotent stem cells and organoid cultures conjugated with single-cell and spatial transcriptomics. Your research will contribute to shed light on early germline development and pave the way for developing efficient protocols for in vitro gametogenesis. You will work under the supervision of assistant professor João Pedro Alves-Lopes, who is leading this project and line of research in the lab.

We are seeking a highly motivated and enthusiastic postdoctoral fellow to join our research team. The ideal candidate should possess a critical mind and a passion for advancing scientific knowledge. The successful candidate will actively engage in scientific discussions, fostering a collaborative environment with other team members. Strong communication skills are essential, as the role involves not only contributing to cutting-edge research but also sharing insights and discoveries with colleagues. The ability to supervise and mentor master’s and Ph.D. students is a key aspect of this position, making it an excellent opportunity for individuals eager to contribute to both their academic growth and the development of emerging researchers. If you are a dedicated researcher with a commitment to excellence, innovation, and collaboration, we invite you to apply and be part of our scientific journey.

We are looking for a candidate with the following set of skills:

• Experience in maintaining and differentiating human pluripotent stem cells.
• Expertise in establishing and maintaining human organoid cultures and 3D cell cultures.
• Demonstrated skills in histological techniques, including cryosectioning.
• Proficient in operating confocal microscopy equipment and analysing imaging data.
• Experience in utilizing Fluorescence-Activated Cell Sorting (FACS) for cell sorting and analysis.
• Expertise in preparing libraries for single-cell RNA sequencing.
• Competence in molecular biology techniques, including cloning methodologies.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna, Stockholm

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page) taking in consideration the following questions:
  o How does your current research align with the topic of the project described here?
  o Can you provide examples of how you have applied innovative approaches or        methodologies in your current research?
  o How are you collaborating with current team members in your current research?
• A motivation letter explaining (no more than one page)
  Why are you the ideal candidate for this position?
  Why are you interested in this position?
  What are your ambitions with this position?

Welcome to apply at the latest March 5, 2024

The application is to be submitted through the Varbi recruitment system.