Postdoctoral Researcher in single-cell epigenomics

Are you interested in non-genetic cellular heterogeneity and their role in disease? Would you like to contribute to the development of cutting-edge epigenetic technologies?  Come and join us at SciLifeLab.

The Department of Microbiology, Tumor and Cell Biology conducts research and teaching in immunology, infection biology, cell biology and cancer. MTC has about 430 active employees, including 100 PhD students, 50 postdoctoral researchers and 26 professors. Our laboratory is located at the Science for Life Laboratory (SciLifeLab, http://www.scilifelab.se/ ) in the Karolinska Institute campus. SciLifeLab is equiped with state-of-the-art instrumentation and core facilities, and is home to one of the largest sequencing cluster in Europe. SciLifeLab Stockholm is a joint effort between Karolinska Institute, the Swedish Royal Institute of Technology (KTH) and Stockholm University, and hosts research groups with diverse backgrounds and expertise, including basic biology, drug discovery, genomics, bioengineering, and translational medicine.

Our group combines experimental and computational work, and aims to develop and apply novel genome-wide techniques to address fundamental biological questions with medical implications. We are especially interested in how subtle variations in gene expression can lead to differential cellular phenotypes (http://pelechanolab.com/ ). You will have the opportunity to work in a highly interdisciplinary and international environment and combine the development of state-of-the art genome-wide approaches with the molecular dissection of fundamental biological problems.

The available postdoctoral position concerns developing and applying novel genomic approaches to study the impact of epigenetics and chromatin organization in cell-to-cell phenotypic heterogeneity. The candidate will focus on the development and application of novel tools to study the heterogeneity of chromatin marks and Transcription Factor/co-factor interactions in human cells. The candidate will use, and contribute to, novel genome-wide methods that our lab is developing to study chromatin organization at single-molecule level and integrate it with novel CRISPR based approaches. The candidate is expected to contribute his/her own ideas to the common goal of understanding how epigenetic heterogeneity contributes to the appearance of differences across clonal populations of cells. The candidate will perform original research in genomics, and acquire the required experimental and computational skills necessary for the completion of the project. The candidate will be responsible for the experimental design, implementing analytical pipelines and integrate different kinds of genomic data to answer biologically relevant questions. The successful candidate will take a strong lead in the experimental design, and collaborate with other team members. The candidate is expected to communicate the scientific results by writing up scientific papers and attending scientific meetings. The ideal candidate is also expected to participate in the general duties of the team and to effectively communicate with scientists of very diverse backgrounds in a highly interdisciplinary and international environment. Working language is English.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

Applicants to this position should have a PhD in Molecular Biology, Genetics, or related fields.

The successful applicant should have experience interpreting biological data and experimentally testing their hypothesis. Previous experience in CRISPR technologies, Eukaryotic transcriptional regulation and chromatin organization will be highly considered. A strong interest in interdisciplinary technology development, and novel and creative thinking abilities are essential. Preferred experience also includes familiarity with epigenetics, single-cell RNA sequencing, ATAC-Seq, Cut&Tag, PLA, flow-cytometry, bioinformatics, NGS data analysis and molecular biology techniques. Good interpersonal skills and ability to work in teams is essential. Previous experience in DNA damage and repair will be meriting. This is an excellent opportunity for an individual with experience in genomics to expand his/her ability to design and interpret novel experimental approaches. Applicants wishing to integrate experimental and computational biology approaches are also encouraged to apply.

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Solna

Science for Life Laboratory (http://www.scilifelab.se/ ) in the Karolinska Institute Solna campus.

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.