Postdoctoral Researcher in RNA biology and genomics

The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet conducts research and teaching within immunology, infection biology, cell biology and cancer. MTC have about 40 research groups and our key words are multidisciplinary, bridging, national and international collaborations.

The research group of Dr Claudia Kutter is looking for a Postdoc (computational/experimental) in the field of RNA biology, functional genomics and regulatory transcriptomics. The Kutter lab is at the forefront in deciphering molecular mechanism by which RNAs (i.e. long noncoding, transfer and small RNA) regulate genes and genome structure in both health and diseases (Geng et al. LSA 2024, Geng et al. Genome Research 2022, Søndergaard et al. Gut, 2022, Gao et al. Genome Research 2022). The successful candidate will be part of a multidisciplinary and collaborative research team active within the fields of chromatin and RNA biology, genomics and transcriptomics, and CRISPR technologies.

As a Postdoc in the Kutter lab, you will apply, optimize and integrate novel transcriptome-wide approaches (based on bulk and single cell RNA-sequencing) to study gene expression and transcript regulation using data obtained from patients and cell models. This project focusses on the roles of regulatory RNAs in genome organization.

The Kutter lab interrogates genome- and transcriptome-wide regulation and functionality by employing a combination of next generation sequencing technologies (both bulk and single-cell) and high-throughput genetic screening approaches, develops computational methods, along with applying experimental techniques. The group uses an integrative and collaborative approach, works closely with computational and experimental groups at KI, Science for Life Laboratory (SciLifeLab), and other local and international research groups. Frequent courses are provided on campus. Additional professional training is available through summer schools and recurrent workshops.

The laboratory is located at SciLifeLab on the Karolinska Institute campus in Solna, Stockholm. SciLifeLab offers an attractive research environment, provides state-of-the-art instrumentation and core facilities, and is home to the second largest sequencing cluster in Europe. SciLifeLab is a joint effort between Karolinska Institute, the Swedish Royal Institute of Technology, and Stockholm University. It hosts research groups with diverse backgrounds and expertise, creating a unique interface between basic biology, genomics, bioengineering, drug discovery, and translational medicine.

To be eligible for employment as a postdoctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.

Requirements

• We are looking for a postdoc with strong background in genomics, computational biology, and/or statistics as well as experience in high-throughput sequence and gene expression data analysis techniques is a demand.
• Excellent skills in programming (primarily R/Bioconductor, Python, UNIX), knowledge of biological databases and data integration as well as data visualization is required.
• The ideal candidate has strong expertise in RNA biology, sequencing and CRISPR technologies.

In the role as postdoc, you will take a strong lead in the project design and management as well as data generation, analyses, and interpretation, participate in the general duties of the team and collaborate with other groups (national and international) and team members (e.g., as co-supervisor). The applicant is expected to report the scientific results leading to scientific manuscripts, attending scientific meetings, and effectively communicate with peers. The ability to work in a highly interdisciplinary and international environment, and to engage in continuous professional development is a must.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna

For more information on the work of the laboratory, please visit: https://www.scilifelab.se/researchers/claudia-kutter/

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)
• Contact information of three referees
• Copy of degree certificates

Welcome to apply at the latest 2024-02-19

The application is to be submitted through the Varbi recruitment system.