Postdoctoral Researcher in Receptor Pharmacology

In the division “Receptor Biology & Signaling” headed by Prof Gunnar Schulte, G protein-coupled receptors and particularly Class F receptors are in focus. The work aims to better understand how ligands interact with Class F receptors, how conformational changes are established to activate the receptors and consequently to initiate interaction and activation of intracellular signaling components. Functional selectivity of Class F receptors towards heterotrimeric G proteins or other pathways are analyzed with the hope to exploit the novel knowledge therapeutically.
For more information: https://ki.se/en/fyfa/schulte-lab 

The research project is aiming to understand underlying molecular details of Class F receptor activation for future drug development. It is embedded in the EUbOPEN project (https://www.eubopen.org/ ), which provides the integration of the project into medicinal chemistry, chemogenomics, compound identification and validation, drug discovery, and structural biology. The highly motivated candidate, with a strong background in medicinal chemistry and GPCR pharmacology, is expected to drive the research project, technical development and concept development from idea to publication. The candidate’s broad expertise in wet laboratory and assay development is expected to serve as a resource for the research team. The candidate will participate in supervision of masters and PhD students. In addition to lab work, the applicant is expected to take an active, constructive and developing part in lab management.

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

The applicant should have a profound background in medicinal chemistry, biochemistry, molecular biology, and cell biology with emphasis on GPCR pharmacology. Solid experience in cell culture, protein biochemistry, resonance energy transfer-based (FRET/BRET) techniques, ligand binding experiments, cloning, assay design and assay validation are required. Documented experience (previous high quality publications) with GPCR pharmacology and protein biochemistry is a requirement.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna, Biomedicum

An employment application must contain the following documents in English or Swedish:

• A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

Welcome to apply!

The application is to be submitted through the Varbi recruitment system.