Do you want to contribute to top quality biomedical research?

Applications for a core bioinformatician position is welcome at unit of Molecular Neurobiology (MBB), at Karolinska Institutet, Stockholm, Sweden, at the Gonçalo Castelo-Branco research group .

The successful candidate will be actively working in specific projects with single-cell transcriptomics and epigenomics, and will be integrated in a multidisciplinary team comprising computational, molecular and cellular biologists. The core bioinformatician will work on web development, data curation, handling of data integration and visualization frameworks, among other tasks. Previous experience as bioinformatics engineer in core facilities and/or in research groups is a requirement

We are looking for highly motivated, driven, inquisitive, enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidate should have a collaborative approach to research, working productively in a team and contributing to a good social environment in the laboratory.

The applicants must have at least a Bachelor or Master in the areas of bioinformatics, computational biology, biotechnology, or similar, and strong programming skills (R and/or Python and/or others), UNIX and LINUX systems knowledge, familiarity with data science a big data. Research experienceand expertise in analysis of single-cell sequencing data is highly desirable.

A creative and inspiring environment full of expertise and curiosity. Our research group is based at the Department of Medical Biochemistry and Biophysics (MBB), at the Karolinska Institutet (KI), Stockholm, Sweden, within the Unit of Molecular Neurobiology.

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is a state university, which entitles to several benefits such as extended holiday and generous occupational pension. Employees also have access to our modern gym for free and receive reimbursements for medical care.

The Unit of Molecular Neurobiology has presently seven research groups, focused on several aspects of development, stem cell biology, neuroscience and cancer, providing a unique critical mass and expertize, and vibrant scientific environment.

The Castelo-Branco research group is interested in the molecular mechanisms defining the epigenetic state of cells of the oligodendrocyte lineage. We are focused on how interplay between transcription factors, non-coding RNAs and chromatin modifying enzymes contribute to the transition between states within the oligodendrocyte lineage, with the aim to design epigenetic based-therapies to induce regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis. Our research group has performed single nuclei/cell omics and identified several cell states within the oligodendrocyte lineage in development and disease (Science 2016, Dev Cell 2018, Nature Medicine 2018, Nature 2019, Nature Biotechnology 2021, Neuron 2022). Our findings suggest that oligodendrocyte lineage cells might present other functional properties than previously thought.

Location: Biomedicum, Stockholm, Sweden

Application

Welcome to apply at the latest May 4th 2022

An employment application must contain the following documents in English:

• A complete curriculum vitae
• A personal letter highlighting previous scientific accomplishments, technical expertize and why the candidate is interested in joining the host lab (no more than one page) 

Permanent position is initiated by a six months trial period.