3-YEAR TECHNICIAN POSITION STUDYING CELLULAR SENESCENCE AND AGEING

Center for Biological Research "Margarita Salas"-CSIC, Spain

Updated: 4 months ago
Job Type: FullTime
Deadline: 15 Jun 2023

1 Jun 2023
Job Information
Organisation/Company

Center for Biological Research "Margarita Salas"-CSIC
Department

Funding & Resources Unit
Research Field

Biological sciences » Biology
Researcher Profile

First Stage Researcher (R1)
Country

Spain
Application Deadline

15 Jun 2023 - 17:00 (Europe/Madrid)
Type of Contract

Permanent
Job Status

Full-time
Hours Per Week

37,5
Offer Starting Date

1 Sep 2023
Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

A lab technician contract is offered in the research group "Epigenetics and Cellular Senescence Lab" at the Center for Biological Research (CSIC) in Madrid. The contract will be carried out through the CSIC and will be charged to the project of the State Research Agency (Project PID2021-125656OB financed by MCIN/AEI/ 10.13039/501100011033/FEDER,UE).

Aging is a process of cellular and tissue dysfunction, which presents several characteristics, such as the activation of cellular senescence. Senescence is a process by which cells stop proliferating and produce a particular secretome. Our laboratory has recently identified that small extracellular vesicles (sEVs) serve as a cellular communication mechanism between senescent cells and proliferating cells. In this project, we propose to study the metabolomic changes produced during aging in human cells and in mouse tissues. For them, metabolomics, gene editing (CRISPR/Cas), proteomics and single-cell RNA sequencing (scRNAseq) studies will be carried out.

 


Requirements
Research Field
Biological sciences » Biology
Education Level
Bachelor Degree or equivalent

Research Field
Biological sciences » Biology
Education Level
Undergraduate

Skills/Qualifications

For this, we are looking for a highly motivated and organized person, capable of working independently, but also in a team. Experience in some of the following techniques will be valued, although it is not an essential requirement: use of primary cultures, infections with lentiviruses and/or retroviruses, isolation of extracellular vesicles and/or work with experimental animals. 

Recent group posts:

1. Fafián-Labora J, ... O'Loghlen A. (2020) Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage. Cell Metabolism 32(1):71-86.e5. Research highlight in Nat Rev Mol Cell Biol. Selected in “Focus in Aging” issue (Cell Metabolism).

2. Fafián-Labora J and O'Loghlen, A.* (2020) Classical and Nonclassical Intercellular Communication in Senescence and Aging. Trends in Cell Biology 30(8):628-39

3. Borghesan M, ... O'Loghlen, A*. Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence. 2019; Cell Reports 27, 3956–3971

 


Languages
ENGLISH
Level
Good

Additional Information
Work Location(s)
Number of offers available
1
Company/Institute
Spanish National Research Centre (CSIC - CIB)
Country
Spain
State/Province
Madrid
City
Madrid
Postal Code
28040
Street
Calle Ramiro de Maeztu 9

Where to apply
E-mail

ana.ologhlen@cib.csic.es

Contact
State/Province

Madrid
City

Madrid
Website

https://sites.google.com/view/theologhlenlab
Street

9th Ramiro de Maeztu,
Postal Code

28040
E-Mail

ana.ologhlen@cib.csic.es

STATUS: EXPIRED
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