On the frontiers of nanomedicine: nanoscopy of nano-bio interactions

Institute of Physics Slovak Academy of Sciences, Slovakia

Updated: 28 days ago
Job Type: FullTime
Deadline: 10 Apr 2024

29 Mar 2024
Job Information
Organisation/Company

Institute of Physics Slovak Academy of Sciences
Department

Department of Multilayers and Nanostructures
Research Field

Physics » Biophysics
Physics » Chemical physics
Chemistry » Physical chemistry
Researcher Profile

First Stage Researcher (R1)
Country

Slovakia
Application Deadline

10 Apr 2024 - 12:00 (Europe/Bratislava)
Type of Contract

Temporary
Job Status

Full-time
Hours Per Week

30
Offer Starting Date

1 Sep 2024
Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Photothermal therapy triggered by irradiation of bioconjugated nanomaterials can offer a breakthrough solution in the currently available cancer therapies. Up until now nanomedicine-oriented works lacked detailed nanoscale investigations of conjugates’ binding dynamics, self-assembled structures, composition and organization of proteins, nanoparticle-protein complexes, and the nanoimaging of phototherapy induced changes in molecular bonds and nano-bio assemblies. This work encompasses the study of the properties and activity of MoOx and MXene-based nano-bio conjugates on a fundamental nano-level, in order to understand particular phenomena, including their interaction with cells. The candidate will master nanoparticle and conjugate design and their in-depth characterization (physical, chemical, biological). Advanced microscopy techniques will be used, such as Confocal Raman Microscopy, AFM Force Spectroscopy, correlative CRM-AFM and near field scanning optical imaging. This proposed topic allows the candidate to extend his/her knowledge through original research and critical analysis. The work will be realized at the Institute of Physics, Slovak Academy of Sciences. For detailed information, please contact: [email protected]

Literature:

  • Annušová et al, ACS Omega, 2023, 8, 47, 44497–44513, doi: 10.1021/acsomega.3c01934;
  • Nan et al, Appl Spectrosc Rev, 2021, 56, 7, 531–552, 2021, doi: 10.1080/05704928.2020.1830789;
  • Lamprecht, C. et al., Biomedical Sensing with the Atomic Force Microscope, in Bhushan B. (eds) Nanotribology and Nanomechanics. 135–173 (Springer, 2017)

Requirements
Research Field
Physics » Chemical physics
Education Level
Master Degree or equivalent

Research Field
Physics » Biophysics
Education Level
Master Degree or equivalent

Research Field
Chemistry » Physical chemistry
Education Level
Master Degree or equivalent

Skills/Qualifications

We seek an openminded, team-spirited PhD candidate with:

  • Masters degree or equivalent in Physics, Chemistry or Biophysics or strong interest in physics of nanostructures.
  • Excellent command of English and teamwork skills (time management, problem solving, critical thinking).
  • Previous experience in a research environment involving material research, nanomaterials, biophysics or similar will be positively considered.

Specific Requirements
  • AFM, Raman, Ellipsometry, UV-Vis spectrophotometry expertise are welcomed.
  • Programming experience considered an asset.

Languages
ENGLISH
Level
Excellent

Additional Information
Benefits
  • Acquire a doctoral degree at the Comenius University in Bratislava and participate in the PhD program of the Institute of Physics SAS.
  • Become part of a supportive and stimulating interdisciplinary team of physicists, chemists and biologists developing next-generation cancer diagnosis and treatment systems.
  • Benefit from state-of-the-art equipment, facilities and capabilities.
  • We offer opportunities for personal growth, professional development, international networking.
  • Competitive salary, on campus accommodation.

Selection process

Please send your CV, publication list and cover letter to Adriana Annušová by email: [email protected]


Additional comments

The term of employment is 4 years with the possibility of extension. Preferred start September 1, 2024.


Work Location(s)
Number of offers available
1
Company/Institute
Institute of Physics, Slovak Academy of Sciences
Country
Slovakia
City
Bratislava
Postal Code
84511
Street
Dúbravská cesta 9
Geofield


Where to apply
E-mail

[email protected]

Contact
City

Bratislava
Website

https://www.savba.sk/
Street

Dúbravská cesta 9
Postal Code

845 11
E-Mail

[email protected]

STATUS: EXPIRED

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