11 Apr 2024
Job Information
- Organisation/Company
University of Oslo- Research Field
Medical sciences- Researcher Profile
Recognised Researcher (R2)- Country
Norway- Application Deadline
2 May 2024 - 23:00 (Europe/Oslo)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
37.5- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
A postdoctoral position is available to study DNA repair and treatment-induced tumor evolution in mammalian cells and tissues in Hilde Loge Nilsen research group at the Department of Microbiology.
The group works with DNA repair, specifically with the repair of uracil, resulting from cytosine deamination, initiated by uracil-DNA glycosylase. We are particularly interested in the interaction between uracil repair and APOBEC cytosine deaminases. APOBEC enzymes accelerate tumor evolution by generating uracil in DNA and footprints of APOBEC activity can be seen in cancer cells as specific mutational signatures. We have recently shown that APOBEC activity can drive tumor development in mice.
In this project, which is funded by the Norwegian Cancer Society, we want to find out whether we can utilize the balance between APOBEC and uracil-DNA glycosylase activity to inhibit development of therapy resistance in chronic lymphocytic leukaemia.
The work includes using gene editing tools to create cell lines with altered balance between APOBEC activity and uracil-DNA glycosylase and use these to analyze the molecular mechanisms that contribute to the development of treatment resistance.
For more information and how to apply: https://www.jobbnorge.no/en/available-jobs/job/260836/postdoctoral-fellowship-to-study-dna-repair-and-treatment-induced-tumor-evolution
Requirements
- Research Field
- Medical sciences
- Education Level
- PhD or equivalent
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Institute of Clinical Medicine (Klinmed)
- Country
- Norway
- Geofield
Where to apply
- Website
https://www.jobbnorge.no/en/available-jobs/job/260836/postdoctoral-fellowship-t…
Contact
- City
Oslo- Website
https://www.med.uio.no/klinmed/english/- Street
PO box 1072 Blindern- Postal Code
NO-0316
[email protected]
STATUS: EXPIRED
Similar Positions
-
Postdoctoral Fellowship To Study Dna Repair And Treatment Induced Tumor Evolution , University of Oslo, Norway, about 15 hours ago
2nd May 2024 Languages English English English Department of Microbiology, Division of Laboratory Medicine, Institute of Clinical Medicine, Postdoctoral Fellowship to study DNA repair and treatmen...
-
Postdoc Position In Natural Killer Cell Biology And Cell Therapy, University of Oslo, Norway, 1 day ago
powered by: Cookie Information Nettsiden bruker cookies Vi ønsker at du skal være trygg når du bruker dette nettstedet. Vi benytter cookies for å sikre at du får en best mulig brukeropplevelse og ...
-
Postdoc Position In Natural Killer Cell Biology And Cell Therapy , University of Oslo, Norway, about 15 hours ago
8th May 2024 Languages English English English Postdoc position in natural killer cell biology and cell therapy Apply for this job See advertisement The Precision Immunotherapy Alliance (PRIMA) PR...
-
Postdoctoral Fellow 3 Year Position In Drug Screening Using Biliary Organoids, University of Oslo, Norway, 1 day ago
powered by: Cookie Information Nettsiden bruker cookies Vi ønsker at du skal være trygg når du bruker dette nettstedet. Vi benytter cookies for å sikre at du får en best mulig brukeropplevelse og ...
-
Postdoctoral Fellow 3 Year Position In Drug Screening Using Biliary Organoids , University of Oslo, Norway, about 15 hours ago
15th May 2024 Languages English English English Postdoctoral fellow - 3 year position in drug screening using biliary organoids Apply for this job See advertisement Job description Do you want to ...
-
Research Assistant In Dna Based Biodiversity Analyses, University of Oslo, Norway, 1 day ago
powered by: Cookie Information Nettsiden bruker cookies Vi ønsker at du skal være trygg når du bruker dette nettstedet. Vi benytter cookies for å sikre at du får en best mulig brukeropplevelse og ...