Phd research fellow in the SFF Centre for Embryology and Healthy development (CRESCO)

• English

A 3-year Ph.D. position is available at the Centre for Embryology and Healthy Development (CRESCO; recently launched Norwegian Centre of Excellence). The candidate will work in the Stem Cells, Ageing and Cancer group under the supervision of Deputy Centre Director and Associate Professor Lorena Arranz, located at the Institute of Clinical Medicine, Faculty of Medicine, University of Oslo. The team of co-supervisors will include Centre Director and Professor Arne Klungland and other researchers.

CRESCO will explore the role of dynamic epigenetic and epitranscriptomic modifications in oocytes, embryos and stem cells, unraveling their functional impact on embryogenesis, stem cell function and malignancy. Our One-Health approach will investigate model organisms, livestock, and human embryogenesis and health, fostering collaborations across basic research and medicine.

This Ph.D. project will focus on understanding the expression control of selected genes in the development of acute myeloid leukemia in human patients. The Ph.D. project is a follow-up of our recent findings (Villatoro et al., Nat Commun, 2023).

The candidate will learn and perform mouse and human stem cell function work ex vivo and in vivo, including gold standard techniques like transplantation and xenograft. Additionally, the candidate will apply CRISPR edition on healthy and malignant stem cells and use their knowledge to contribute to improve current CRISPR techniques to long-term hematopoietic stem cells.

In particular, the candidate will focus on deciphering the role of selective gene variants and epigenetic mechanisms on stem cell transformation and acute myeloid leukemia pathogenesis. In the future, this work will help select the patients with best chances of success for selective therapies to be tested in clinical trial.

The candidate will work with experts in the field of stem cell biology, epigenomics and CRISPR, and will enjoy a close collaboration within a dynamic and ambitious team recently transitioned to the University of Oslo. Our labs are physically located at SINTEF, Forskningsveien 1, Oslo.

The research fellow must take part in the Faculty’s approved PhD program and is expected to complete the project within the set fellowship period. The main purpose of the fellowship is research training leading to the successful completion of a PhD degree.

• Master’s degree in molecular biology/molecular medicine.
• FELASA certificate to work with mice
• Experience with stem cells, hematopoietic stem cells in particular
• Basic molecular biology techniques, such as Nucleic acid extraction, qPCR, western blot
• Experience with CRISPR
• Experience with working in multi-disciplinary teams
• Professional written and verbal English language competency

The following qualifications will be considered desirable:

• Experience with bioinformatics in addition to molecular biology or (bio)medicine.
• Experience with mouse models

• Highly motivated 
• Self-driven
• Team worker

• An ambitious and stimulating research environment
• Salary NOK 532 200 – 575 400 per annum in a position code SKO 1017 depending on qualifications
• Favorable pension arrangements (Statens Pensjonskasse) 

• Advantageous welfare conditions

More information can be found here: http://www.uio.no/english/for-employees/employment/

The application must include the following:

• Master degree transcript
• Cover letter stating your motivation, scientific background, and research interests,
• A detailed CV, 2-3 references (name, institution, e-mail, telephone number, and relation to the candidate)

The application with attachments must be submitted in English and uploaded in pdf format in our electronic recruiting system linked in the announcement. Please follow the link “apply for this job.”

While the recruitment system includes a basic CV, we ask candidates to include a detailed CV in pdf format with their application. Applications without a cover letter and detailed CV will be rejected.

Eligible applicants might be called in for an interview.

Please see the guidelines and regulations for appointments to Research Fellowships at the University of Oslo.

No one can be appointed for more than one PhD Research Fellowship period at the University of Oslo.

According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.

The appointment may be shortened/given a more limited scope within the framework of the applicable guidelines on account of any previous employment in academic positions.

The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.

Inclusion and diversity are a strength. The University of Oslo has a personnel policy objective of achieving a balanced gender composition. Furthermore, we want employees with diverse professional expertise, life experience and perspectives.

If there are qualified applicants with disabilities, employment gaps or immigrant background, we will invite at least one applicant from each of these categories to an interview.

For any informal inquiries regarding the position, please contact;

Associate Professor Lorena Arranz, e-mail:[email protected]

For questions regarding the application process, please contact;

HR senior adviser Mija Nikolaisen, tel. +47 22844687, e-mail: mija.nikolaisen@medisin

The University of Oslo is Norway’s oldest and highest ranked educational and research institution, with 28 000 students and 7000 employees. With its broad range of academic disciplines and internationally recognised research communities, UiO is an important contributor to society.

The Institute of Clinical Medicine (Klinmed) is one of three institutes under the Faculty. Klinmed is responsible for the Faculty's educational and research activities at Oslo University Hospital and Akershus University Hospital. With about 800 employees spread over approximately 425 man-labour years, Klinmed is the university's largest institute. Our activities follow the clinical activity at the hospitals and are spread across a number of geographical areas.

4th March 2024

University of Oslo

Oslo

Scope

Fulltime (1 positions) Fulltime (%)

Permanent

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