21 Mar 2024
Job Information
- Organisation/Company
University of Oslo- Research Field
Medical sciences- Researcher Profile
First Stage Researcher (R1)- Country
Norway- Application Deadline
21 Apr 2024 - 23:00 (Europe/Oslo)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
37.5- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Development of cancer requires pre-cancerous cells to evolve ways to circumvent the limited replicative lifespan of human somatic cells. In up to 80–90% of cancers this is mediated by overexpression of the telomerase multiprotein-RNA complex, which elongates chromosomal ends using an RNA template.
Although targeting the telomerase pathway is a promising strategy for cancer treatment, to date, no pharmacological options for disrupting oncogenic telomerase activity have been approved for regulatory use, despite significant advancements in this field. However, we have recently demonstrated that deficiency specific DNA damage proteins leads to defects in RNA quality control, which affects the stability of the telomerase RNA-component, conferring telomere dysfunction and cellular growth arrest. The key knowledge need is to translate this finding into a therapeutic application.
For more information and how to apply: https://www.jobbnorge.no/en/available-jobs/job/259850/phd-research-fellow-in-dna-repair-and-telomere-stability-in-cancer
Requirements
- Research Field
- Medical sciences
- Education Level
- Master Degree or equivalent
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Institute of Clinical Medicine (Klinmed)
- Country
- Norway
- Geofield
Where to apply
- Website
https://www.jobbnorge.no/en/available-jobs/job/259850/phd-research-fellow-in-dn…
Contact
- City
Oslo- Website
https://www.med.uio.no/klinmed/english/- Street
PO box 1072 Blindern- Postal Code
NO-0316
[email protected]
STATUS: EXPIRED
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